The Biochemistry and Molecular Biology Problem-Based Learning Resources page is designed to support the three objective areas defined by the curriculum.
Check back often for resource page updates! [External links to resources are added (by me) and deleted (by them).]
For more information concerning these objectives see PBL: A Student Guide.
As your tutor group works through an Electronic Problem-Based Learning Module (ePBLM), learning issues (LI) will be developed. Some groups (as well as some of the cases) are better at this than others. Some groups (and some of the cases) lose focus from time-to-time and important issues are lost in the shuffle.
In order to foster your ability to develop LI and build a knowledge base in biochemistry, including cell and molecular biology (USMLE Step 1 content outlines), I have created unit LI grids, featured topics, major points, and correlated readings. One can build a foundation by learning about specific topics or by asking questions pertinent to each case. You should note that many of the potential LI appear in multiple cases and across units. You have multiple opportunities to encounter these topics, so don't think that you must completely cover them with any particular case. Note that the link to a PBLM resource page will be activated as tutor groups process that particular case. If you try to open a page too early, it will automatically transfer back to the main unit page.
|Biocarta cellular and metabolic pathways|
|Corrrelated readings for clinical laboratory tests|
|emedicine for diagnoses and differentials|
|Food and nutrition information center (USDA)|
|Lab Tests Online|
|Metabolic Pathways (Roche.com)|
|The Medical Biochemistry Page (for details of pathways)|
|Stanford Pathways of Human Metabolism|
|Urinalysis (University of Utah)|
|USDA National Nutrient Database|
|USMLE content outline (for Step licensure examinations; pdf, 1.1 MB)|
|USMLE laboratory values (for Step licensure examinations; pdf, 234 KB)|
|Videos of surgical procedures|
I recommend the following textbooks for biochemistry and cell and molecular biology:
If you have a background in biochemistry use:
If you DO NOT have a background in biochemistry use:
High quality references/board review books:
The following textbooks are also useful:
|Correlated readings for Clinical Laboratory Tests|
The following may be quite useful also:
For those of you interested in molecular structures, visit the PDB Molecule of the Month. Structures and descriptions that you may be interested in include the following:
|cytochrome c oxidase||restriction enzymes|
|glycogen phosphorylase||serum albumin|
A collection of macromolecules (proteins and nucleic acids) is available at "Chime Square."
Most of what you will encounter in biochemistry has as its foundation the concept of molecular interactions. How do molecules get together, stay together, carry out reactions, define identity, and transduce signals? It would be wise to have an understanding of the building blocks including amino acids, carbohydrates, lipids, and nucleic acids.
Remember, learning content is important in developing an understanding of concepts, both of which serve as a proxy for reflecting your ability to manage and care for patients. As the year progresses, you should be building an effective reading knowledge of biochemistry, including cell and molecular biology. By the end of Y1, you will have encountered a wealth of pertinent information.
Biochemistry and Molecular Biology Resources
Submit your questions and comments to the following: