End-Of-Unit Topics

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I anticipate the following topics will be assessed on the end-of-unit examination based upon the posted final learning issues:

End-of-unit topics
 Topic  Description  PBLM

Acetylcholine synthesis and receptor

biosynthetic pathway of acetylcholine, importance of enzymes and coenzymes, acetylcholine receptor properties

James, Anderson, Souders, Franks, Huff

Alcohol processing and effect on metabolic pathways

biodegradation pathway of ethanol, effects of NADH on glycolysis, gluconeogenesis, tricarboxylic acid cycle, transport of reducing equivalents to electron transport chain

Bernard

Dystrophin - connection to extracellular matrix

dystrophin and sarcolemma complexes and interactions, detection methods, clinical markers

Anderson
biosynthetic pathway of ketone body production in liver and utilization in nervous tissue
Bernard
general pathways and gross regulation of energy production in muscle and nervous tissue, role of calcium, vitamins and nutrition
James, Anderson

Neurotransmitter synthesis (in Vitamins), storage and release

biosynthetic pathway of neurotransmitters, emphasis on acetylcholine, dopamine (and related catecholamines), gamma-aminobutyric acid, glutamate, and serotonin, associated enzymes, coenzymes and micronutrients, molecular features of packaging and release

James, Anderson, Souders, Franks, Vision mc, Huff, Bernard, Halloran

Prostaglandins, leukotrienes, and thromboxanes - aspirin/steroids

biosynthetic pathway to prostaglandins, leukotrienes, and thromboxanes, effects of NSAIDs (aspirin) and steroids, comparison of COX enzymes
James, Anderson, Souders, Franks, Huff

Signal transduction of gustation, olfaction, phototransduction

molecular features and comparison of taste, smell, and vision pathways

Franks, Vision mc

Vitamins

role of vitamins (A, Bs, C, choline) on general metabolic pathways and neurotransmitter synthesis

James, Anderson, Souders, Franks, Vision mc, Huff, Bernard, Halloran

I suggest, as I have done so previously in the help sessions, that you would do well to be familiar with the content and concepts that appear on the PowerPoint animations that are available on this web site. My help sessions focused on these topics, which were the consensus learning issues. Self-assessment questions and answers (SAQs) have been available for your practice.

If you need additional resources, please contact me and I encourage you to read each case's correlated readings in Devlin (Devlin, T. M. (ed.). 2002. Textbook of biochemistry with clinical correlations, 5th ed. John Wiley & Sons, Inc., New York) or appropriate material in Nelson and Cox (Nelson, D. L., and M. M. Cox. (ed.). 2000. Lehninger principles of biochemistry, 3rd ed. Worth, New York).

 

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