Muscle Biochemistry

Eric C. Niederhoffer, Ph.D.

Associate Professor, Biochemistry & Molecular Biology

Copyright 2001- , E.C. Niederhoffer. All Rights Reserved.
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Dystrophin
  • Protein similarity
alpha-actinins
spectrins
  • Functional domains
amino terminus - 240 aa, binds F-actin
coiled-coiled rod - 2400 aa, longest section provides flexibility and elasticity
cysteine-rich - 280 aa, required for membrane attachment to beta-dystroglycan
carboxy terminus - 420 aa, contains potential phosphorylation sites, binds to syntrophins
  • Function
mechanical reinforcement of sarcolemma (in skeletal muscle)
signal transduction (control of muscle fiber caliber and size)
anchor or stabilizer of dystroglycans and sarcoglycans

 

Biochemistry and Molecular Biology Resources

Submit your questions and comments to the following:
eniederhoffer@siumed.edu