The focus of PU04 is the metabolism of carbohydrates. The material for study is available on-line and may be found in Textbook of Biochemistry with Clinical Correlations edited by Thomas M. Devlin (the Wiley web site has links to additional resources).
Metabolism at a Glance by J. G. Salway is available for $29.95 and is an excellent approach to the metabolism covered in the Problem Units. Blackwell Science Inc. has other titles in their "at a Glance" series.
Be sure to check with the MRC Web site for access to additional curricular materials.
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November 8 9 to 10 am Rm 133 LS I |
November 10 4 to 5 pm Rm 205 LS I |
November 15 9 to 10 am Rm 133 LS I |
November 17 11 to 12 noon Rm 1059 LS III |
November 29 11 to 12 noon Rm 1059 LS III |
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January 4 9 to 10 am Rm 133 LS I |
January 6 9 to 10 am Rm 205 LS I |
January 10 11 to 12 noon Rm 1059 LS III |
January 11 10 to 11 am Rm 133 LS I |
For those of you using the recommended text, material may be found in (but not limited to nor in the listed order of) the following chapters:
| Chapter 6 | Bioenergetics and Oxidative Metabolism |
| Chapter 7 | Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control |
| Chapter 8 | Carbohydrate Metabolism II: Special Pathways |
| Chapter 13 | Metabolic Interrelationships |
| Chapter 26 | Digestion and Absorption of Basic Nutritional Constituents |
| Chapter 28 | Principles of Nutrition II: Micronutrients |
| Appendix | Review of Organic Chemistry |
| In
the first paragraph, the sentence should read, "The result
is a longer amylose chain with only one glucosyl residue remaining in an alpha-1,6 linkage." |
p. 318 |
| Fig
7.53 should indicate that the glucosidase activity of
the debranching enzyme removes the remaining alpha-1,6-linked glucosyl residue at the bottom of the figure. |
p. 318 |
| Clinical
Correlation 8.7 contains the incorrect structure for a typical Asn-GlcNac oligosaccharide. The correct structure appears at the bottom of Clinical Correlation 8.9 on p. 352. (correct version) |
p. 349 |
| Clinical
Correlation 8.9 contains incorrect structures for dermatan sulfate
and heparan sulfate. The correct structure appear at the bottom of Clinical Correlation 8.7 on p. 349. (correct version) |
p. 352 |
I anticipate the use of transparencies and judicious discussions; I encourage you to read the material ahead of time. The topics covered during each lecture are indicated in blue while the anticipated topics for upcoming discussions are listed in red in the table below. Be advised that I plan to record the lectures and post them on the internet so that you will have on-line access).
Click on lecture to listen |
Click on link for full description |
| Lecture 1 (11/8/99) 50 min | Course introduction and carbohydrates |
| Lecture 2 (11/10/99) 51 min | Energy overview and glycolysis |
| Lecture 3 (11/15/99) 48 min | Regulatory features of glycolysis and gluconeogenesis |
| Lecture 4 (11/17/99) 48 min | Metabolism
of other monosaccharides, glycogenesis and glycogenolysis and regulatory features of these pathways |
| Lecture 5 (11/29/99) 32 min | Pentose phosphate pathway and Pacing Quiz |
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| Lecture 6 (1/04/00) 51 min | Sugar
interconversions, complex carbohydrates, glycoproteins and proteoglycans |
| Lecture 7 (1/06/00) 45 min | Energy-rich
compounds, acetyl-CoA, citric acid cycle and regulatory features |
| Lecture 8 (1/10/00) 48 min | Electron transport chain |
| Lecture 9 (1/11/00) 44 min | Oxidative
phosphorylation, nutritional features of and defects in carbon metabolism |
During PU04, you have the opportunity to receive feedback on your learning by the use of an on-line quiz. The quiz is designed to probe various topic areas within carbohydrate metabolism.
You will be provided expert feedback on your learning by the use of a pacing quiz and a final examination. The pacing quiz will be given during the Monday 29 November 1999 session. The final examination will be given during CVR Block 2, from 8 to 10 am on Tuesday 18 January 2000 in Rm 133 LS I. Both the pacing quiz and the final examination will comprise a short-answer-question format and are extracted from the Study Guide, lectures and Textbook of Biochemistry with Clinical Correlations by Devlin. You will need to score 70% or better on the final examination to pass PU04. A recycle examination schedule will be announced by Curriculum Affairs; the format will be 25 short-answer questions.
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Monday 29 November 1999 11 to 12 noon Rm 1059 LS III |
Tuesday 18 January 2000 8 to 10 am Rm 133 LS I |
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Wednesday 8 March 2000 Rm 133 LS I |
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Thursday 13 July 2000 9 to 11 am Rm 205 LS I |
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Problem Unit 4 is available in the form of a pdf (Portable Document Format) document which can be either read online or downloaded from this web site. The documents can be read on both PC's and Mac's with Adobe Acrobat Reader.
| Grading and pacing quiz, Salway resource on metabolism | p. 3 |
| Objectives 6, 7, and 10 | p. 7 |
| Objective 15 | p. 8 |
| GLUT transporter family including tissue distribution | pp. 15-16 |
| NADH described as hydrogen carrier | p. 20 |
| FADH2 described as hydrogen carrier | p. 36 |
| Energy source (ATP) for gluconeogensis | p. 25 |
| Glycogen synthesis expanded to include role of glycogenin and glycan primer | p. 27 |
| Maximum yield of ATP per 0.5 O2 | pp. 48-49 |
| How much ATP really forms from complete oxidation of glucose? | pp. 54-55 |
| Modern P/O ratios for glycerol phosphate and malate-aspartate shuttles | pp. 57-58 |
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