Problem Unit #4

Copyright 1999, E.C. Niederhoffer

Lecture #5

You can click on the link to listen to a RealAudio file of the day's lecture. The following description contains the material discussed and the source of the overheads used during the presentation. You can click on the linked ECN files while listening to the audio.

Code:

D = Devlin (Textbook of Biochemistry with Clinical Correlations)

ECN = Created by me

MV = Mathews & van Holde (Biochemistry)

VV = Voet & Voet (Biochemistry)

Lecture 5 (11/29/99) 32 minutes

Announcements

• Remember to check the Web site for updates to the Study Guide
• Animated Gifs available for selected pathways
• Answers to the Pacing Quiz are posted here and on the PU04 home page

Lecture #4 review (D Figs 7.42, 7.50)

• Metabolism of other monosaccharides (fructose, lactose, mannose)
• Glycogen stores and structure
• Glycogenolysis
• Glycogenesis and storage diseases
• Regulatory features of glycogen metabolism

Pentose phosphate pathway

• Overall pathway summarized (ECN, ECN, ECN, ECN)
• Oxidative reactions, production of NADPH, glutathione, glucose-6-phosphate dehydrogenase deficiency (D Figs 8.01a, 7.05, 11.80, 11.81, 11.82, 8.01b, 8.01c)
• Isomerization and epimerization reactions (D Figs 8.01c, 8.02a)
• Carbon-carbon bond cleavage and formation reactions (D Figs 8.02a, 8.02b, 8.02c, 8.02d)
• Complete oxidation of glucose-6-phosphate to CO₂ (D Fig 8.03)
• Preview of CVR Block 2 material

Remember to look over the Study Guide and textbook sections for additional illustrations that may assist in your understanding of the presented material.

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