Problem Unit #4

Copyright 2000, E.C. Niederhoffer

Lecture #8

You can click on the link to listen to a RealAudio file of the day's lecture. The following description contains the material discussed and the source of the overheads used during the presentation.

Code:

D = Devlin (Textbook of Biochemistry with Clinical Correlations)

ECN = Created by me

MV = Mathews & van Holde (Biochemistry)

VV = Voet & Voet (Biochemistry)

Lecture 8 (1/10/00) 48 minutes

Announcements

• Remember to check the Web site for updates to the Study Guide

Lecture #7 review

• Energy producing and energy utilizing systems
• Thermodynamics and energy-rich components
• Sources and fates of acetyl-coenzyme A, pyruvate dehydrogenase complex
• Tricarboxylic acid cycle

Structure and compartmentation by mitochondrial membrane

• Composition and function (D Fig 6.25)
• Transporters (D Fig 6.27)
• Shuttles (D Figs 6.28a, 6.28b, 6.29, 6.30, 6.31)

Electron transfer

• Oxidation-reduction, free energy
• NADH, FADH₂, iron-sulfur proteins, cytochromes, coenzyme Q (D Figs 6.32, 6.33, 6.34a, 6.34b, 6.35, 6.36a, 6.36b, 6.37, 6.39)
• Electron transport complexes (I-IV), inhibition, reversibility (D Figs 6.40a, 6.40b, 6.41, 6.42, 6.43, 6.44, 6.45a, 6.45b, 6.46)

Preview of lecture 9

• Oxidative phosphorylation
• Nutrition and metabolic defects

Remember to look over the Study Guide and textbook sections for additional illustrations that may assist in your understanding of the presented material.

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