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Youssef Chami, MD

Associate Professor
Program Director, Cardiovascular Fellowship Program; Chief, Division of Cardiology
Vice Chair, Department of Internal Medicine


Lycee Francais (Mission Laique Francaise), Beirut, Lebanon - 1975
Medical School: 
Claude Bernard University, Lyon, France - 1983
Internal Medicine, University of Montreal, Notre Dame Hospital, Montreal Canada - 1983, Internal Medicine and Cardiology, Hospital Cardjologigue, Lyon, France - 1983, Internship, Rotating, Hospital Du Vinatier, Lyon, France - 1982
University of Montreal, Montreal Heart Institute - Cardiology , Medical College of Virginia - Interventional Cardiology


Site Principal Investigator:

2000-2001            Senior PAMI
1999-2000            PRAISE II Trial
1999-2000            ESPRIT Trial
1999-2000            Cachet Trial
1998-1998            ASSENT II Trial
1997-1999            SYMPHONY Trial
1996-1997            PURSUIT Trial (IL 057)

Site Co-Investigators:

Grant from the Medicines Company. "A clinical trial comparing treatment with cangrelor (in combination with usual care) to usual care, in subjects who require percutaneious coronary intervention." Conducted: 2008-Present

Grant from Genentech, Inc: "A Randomized Trial Evaluating Low-Dose IntraCoronary Adjunctive Tenecteplase During Primary PCI for ST-Elevation Myocardial Infarction." Conducted: 2008-Present

Grant from CardioMems. "Cardiomems heart sensor allows monitoring of pressure to improve outcomes in NYHA class III heart failure patients." Conducted: 2008-Present

Grant from Abbott Vascular Devices. "Emboshield and Xact Post Approval Carotid Stent Trial using the Ernoshield" BareWire® Rapid Exchange Embolic and Xact" Rapid Exchange Carotid Stent System." Conducted: 2006-Present

Grant from GlaxoSmithKline. "An Open, Nonrandomized Comparison of Pharmacokinetic Profiles of Carvedilol (SK&F-105517) MR and IR on Repeat Dosing in Chronic CHF Patients and Survivors of an Acute MI and LVD./I Conducted: 2005

Grant from Sterotaxis. "Interventional Cardiology Prospective Data and Analysis for Conventional Cases." Conducted: 2005-2006

Grant from Schering-Plough Research Institue: "A Multicenter, Double-Blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin Monotherapy in High-Rish Subjects Presenting with Acute Coronary Syndrome." Conducted: 2005-Present

Grant from Novartis Pharmaceuticals. "A 6-week, multicenter, randomized, double-blind, parallel-group study to evaluate the combination of valsartan/HCTZ (160/12.5 mg with forced titration to a maximum dose of 320/25 mg) compared to valsartan monotherapy (160 mg with forced titration to 320 mg) as initial therapy in patients with severe hypertension." Conducted: 2005-Present

Grant from Lilly Research Institute. "A Comparison of CS-747 and Clopidogrel in acute coronary syndrome subjects who are undergo percutaneous coronary intercention-TIMI 38." Conducted: 2005-Present

Grant from Cordis. "DEScover Registry Protocol." Conducted: 2005-Present

Grant from the Medicines Company. "A trial fibrillation Clopidogrel Trials with Irbesartan for prevention of Vascular Events - ACTIVE, A parallel randomized controlled evaluation of clopidogrel plus aspirin, with factorial evaluation of Irbesartan for prevention of vascular events, in patients with atrial fibrillation (EFC4912)." Conducted: 2004-Present

Grant from Sanofi-Aventis. "Atrial fibrillation Clopidogrel Trials with Irbesartan for prevention of Vascular Events - ACTIVE, A parallel randomized controlled evaluation of clopidogrel plus aspirin, with factorial evaluation of Irbesartan, for the prevention of vascular events, in patients with atrial fibrillation (EFC4912)." Conducted: 2004-Present

Grant from Guidant. "Carotid RX ACCULINK/ACCUNET Post Approval Trial to Uncover Unanticipated of Rare Events." Conducted 2004-Present

Grant from Centocor: "A multicenter, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of Reteplase and Abeiximab combination therapy with Abeiximab alone administered early or just prior to Primary Percutaneious Coronary Intervention for Acute Myocardiallnfaraction (FINESSE: Protocol No. COl16T40)." Conducted: 2004

Grant from Medtronic. "A Multicenter, Non-inferiority Randomized, Controlled Trial to Evaluate the Safety and Efficacy of the Medtronic AVE interceptor' Coronary Filter System in Subjects with DE NOVO and Restenotic Lesions of Saphenous Vein Grafts." Conducted: 2004

Grant from Spectronectics. "Coronary graft results following atherectomy with laser." Conducted: 2004-2005

Grant from Possis Medical Inc. "AngioJet Rheolytic Thrombectomy in Patients Undergoing Primary Angioplasty for Acute Mvocardtal tnfarctlon." Conducted: 2003-2005

Grant from Aventis Pharmaceutical, Inc. "Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment" Conducted: 20003-2005

Grant from Theragenics. itA Safety and Feasibility Study of Use of the Terasource' Intravascular Brachytherapy System for Prevention of Restenosis Following Successful Percutaneoua Transluminal Angioplasty (PTA) in the Superficial Femoral and Popliteal Arteries." Conducted 2003-2004

Grant from Millennium Pharmaceuticals, Inc. "A randomized trial to evaluate the relative protection against post-PCI microvascular dysfunction and post-PCI ischemia among anti-platelet and anti-thrombotic agents." Conducted: 2003-2004

Aggrastat to Zocor Study: A multicenter, randomized, controlled, double-blind trial to investigate the clinical efficacy and tolerability of early treatment with Simvastatin 40mg daily for 30 Days, followed by Simvastatin 80mg daily thereafter in Tirofiban treated Acute Coronary Syndrome patients who have been randomized to receive Enoxaparin or Unfractionated Heparin in conjunction with Aspirin. Conducted: 2001-2002

CARISA - Conducted: 2000-2001
PYRAMID - Conducted: 2000-2001
Heartbar (effect of Oral Nutrient Supplementation on Exercise Tolerance in patients with Stable Coronary Disease) Conducted: 2000-2001
STEPAMI2 - Conducted: 2000-2001
EPIC Trial - Conducted: 1992-1993
QUIET Trial - Conducted: 1991-1994