James Gilchrist, MD
About me
James Gilchrist, MD is Professor and Chair of Neurology at SIU School of Medicine. He is an active clinician, a diplomate of the American Board of Psychiatry and Neurology and has Certificates of Added Qualification in Clinical Neurophysiology and in Neuromuscular Medicine. He received a B.S. in Biology from the University of Illinois at Urbana-Champaign, and M. D. from Loyola-Stritch School of Medicine in Chicago. He completed his Neurology residency at the Medical College of Virginia, where he was Chief Resident. He completed fellowships in Clinical Neurophysiology at Medical College of Virginia and in EMG Research at Duke University Medical Center. His clinical interests include diseases of nerve, muscle and neuromuscular junction. He is very experienced in EMG studies and has been director of MDA sponsored clinics for over 30 years, including Director of the MDA Care Center at SIU. Dr. Gilchrist conducts clinical research on disorders of the peripheral nervous system, particularly disorders of neuromuscular transmission and the muscular dystrophies. He has been the recipient of research and clinical grants from the Muscular Dystrophy Association of America. He has served on review study sections for the NIH Center for Scientific Review and the FDA. He was an Associate Editor for Muscle & Nerve for 11 years and is the author of over 70 scientific articles and 29 book chapters in the field of neurology and neuromuscular disease.
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Publications
Gilchrist JM, et al. Single Fiber EMG Reference Values: A Collaborative Effort. Muscle Nerve 15:151-161, 1992.;
Gilchrist JM, Pericak-Vance MA, Silverman LM, Roses AD. Clinical and Genetic Investigation in Autosomal Dominant Limb-Girdle Dystrophy. Neurology 38:5-9, 1988.;
Speer MC, Yamaoka LH, Gilchrist JM, et al. Confirmation of Genetic Heterogeneity in Limb-girdle Muscular Dystrophy: Linkage of an Autosomal Dominant Form to Chromosome 5q. Am J Hum Genet 50:1211-1217, 1992.
McClatchey AI, Trofatter J, McKenna-Yasek D, Raskind W, Pericak-Vance M, Gilchrist J, et al. Dinucleotide Repeat Polymorphisms at the SCN4A Locus Suggest Alleleic Heterogeneity of Hyperkalemic Periodic Paralysis and Paramyotonia Congenita. Am J Hum Genet 50:896-901, 1992
Gilchrist JM, Massey JM, Sanders DB. Single Fiber EMG and Repetitive Stimulation in Myasthenia Gravis. Muscle Nerve 17:171-175, 1994.
Gilchrist JM, Perrone M, Ross J. Dynamical Analysis of Neuromuscular Transmission Jitter. Muscle Nerve 18:685-692; 1995.
Stajich JM, Gilchrist JM, Lennon F, et al. Confirmation of Linkage of Oculopharyngeal Muscular Dystrophy to Chromosome 14q11.2-q13. Ann Neurol 40:801-804, 1996.
Hauser MA, Horrigan SK, Salmikangas P, Torian UM, Viles KD, Dancel R, Tim RW, Taivainen A,Bartoloni L, Gilchrist JM, et al. Myotilin is Mutated in Limb Girdle Muscular Dystrophy 1A. Hum Mol Genet 9:2141-7; 2000.
Kwiatkowski TJ Jr, Bosco D, LeClerc AL, Tamrazian E, Van den Berg CR, Russ C, Davis A, Gilchrist J, et al. Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis. Science 323:1205-1208; 2009.
Mellion ML, Silbermann E, Gilchrist JM. Machan J, Leggio L, de la Monte S. Small Fiber Degeneration in Alcohol Related Peripheral Neuropathy. Alcoholism: Clin Exp Res 38:1965-1972; 2014.