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CADRD Research

Current Basic/Translational Science Studies

Soluble Aβ

We are examining the effects of soluble Aβ, present during the early stages of Alzheimer’s disease and a major component of amyloid plaques, on neurotransmission in intact neural systems.  Preliminary data indicate that small amounts of soluble Aβ leads to an immediate increase in extracellular glutamate, the major excitatory neurotransmitter in the brain that may also be responsible for neuron loss in middle- and late- stage Alzheimer’s disease.

Altered Neurotransmission

We are evaluating neurotransmission in mouse models of Alzheimer’s disease throughout disease progression to determine how and when it is disrupted, and how altered transmission correlates with cognition levels.  Early findings indicate that glutamate release is elevated prior to cognitive decline, supporting the glutamatergic system as a potential target for early intervention in Alzheimer’s disease.

Early Intervention

We are studying neurological markers and behavioral testing in mouse models of Alzheimer’s disease to evaluate the efficacy of early intervention, prior to substantial cognitive decline, on short- and long- term disease outcome.

Risk Factors

We are evaluating neurotransmission and other key neurological components in models of risk factors for Alzheimer’s disease, such as diabetes, post-traumatic stress disorder, and aging, to determine the factors that lead to increased risk for developing Alzheimer’s disease.  In conjunction with Dr. Andrzej Bartke, we are also studying models of successful aging to determine the factors that help sustain cognition in advanced age.

Current Research

Does Amyloid-β42 Stimulate Hippocampal Lactate Release?

PI:  Kevin N. Hascup, PhD

Effects of Circadian Clock Disruption on Cognitive Decline in a Mouse Model of Alzheimer's Disease

PI:  Shelley A. Tischkau, BS, MS, MS, PhD

Glutamate Neurotransmission in Alzheimer's Disease Progression

PI:  Erin R. Hascup, PhD

Can Rizule Restore Glutamate Function and Cognition in a Mouse Model of Alzheimer's Disease?

PI:  Erin R. Hascup, PhD

Cellular Senescence, Inflammation, and Neurotransmission in Alzheimer's Disease

PI:  Erin R. Hascup, PhD

 

CADRD Basic/Translational Science Researchers

Erin R. Hascup, PhD - Associate Professor

Kevin N. Hascup, PhD - Assistant Professor

Affiliate Researchers & Laboratories

Andrzej Bartke, PhD, Department of Internal Medicine, Director of Geriatric Medicine Research, SIU School of Medicine, Springfield
Peter Patrylo, PhD, Department of Physiology, SIU School of Medicine, Carbondale
Greg Rose, PhD, Director, Center for Integrated Research in Cognitive & Neural Sciences, Department of Anatomy, SIU School of Medicine, Carbondale

What is a Basic/Translational Science Study?

Basic/Translational science research typically includes studies with specialized tissue techniques, experimental animals, or tissues obtained from human autopsies.  These studies focus on identifying which processes might be occurring that would cause the disease or that might improve treatments for the disease.  The goal is to understand the mechanisms of human diseases using animal models.