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All of Us

(formerly Precision Medicine Initiative)

Background: Precision medicine seeks to capitalize on growing capabilities in the areas of genomics, clinical phenotyping, clinical informatics, EHR availability and interoperability, and mobile health technologies to improve understanding of human health and disease. Improved understanding of the complex interplay of genetic and environmental exposures, beyond those previously available in long-term observational epidemiological research, holds the promise of better prediction, prevention, and treatment of a host of human diseases including coronary heart disease, stroke, numerous cancers, dementing illnesses, arthritis, and other major causes of disability and early death. Internationally, efforts to address the opportunities of precision medicine have led to the assembly of large cohorts in the UK (UK Biobank), the China Kadoorie Biobank, and in a selected sub-population in the US (the Million Veteran Project - MVP). In January 2015, President Obama announced a plan for the Precision Medicine Initiative (PMI) to address this significant scientific opportunity.

The US health system faces a crisis in health disparities that could be ameliorated by greater understanding of the link between genetic underpinnings of disease and the environmental and behavioral milieus in which they operate. Conversely, since minorities are under-represented in biomedical research, there is the risk that discoveries from precision medicine research may further widen disparities unless large numbers of minorities participate in such research.

Project Lead: Illinois Precision Medicine Consortium with Wiley Jenkins, PhD serving as site PI

OPSP Team Members: Christofer Rodriguez, MPH; Amanda Fogleman, MEng

Collaborators: University of Illinois Chicago, Northwestern University, University of Chicago, Blessing Health Systems, Decatur Memorial Hospital, OSF St. Francis, Sarah Bush Lincoln, University of Illinois College of Medicine at Peoria

Goals: Study goals: Recruit, consent, examine, collect biospecimens, and transmit curated data and processed biosamples to the PMI Coordinating and Biobanking Centers, on at least 10,000 people from diverse ethnic, social, and economic backgrounds who are patients in 1 of the 3 Illinois area HPOs (and their affiliates). In accomplishing this aim, we will engage HPO staff, patients, and the general community to generate support for, and participation in, the PMI HPO cohort.

Findings: None yet

Publications: None yet