The Office of Population Science and Policy (OPSP) at Southern Illinois University School of Medicine (SIU SOM) is broadly defined as a research and policy organization dedicated to improving the health outcomes of the residents of central and southern Illinois. The Office works to understand the region SIU SOM serves, design and study optimal approaches to the prevention and treatment of disease, model and disseminate these interventions, and educate future health care providers on the importance of population health to the patients they serve. We use research, scholarship, and innovation to design, implement, study, and model solutions to our region’s health challenges. The Office’s ultimate goal will be providing opportunities for healthier, happier, and more successful lives for the residents of central and southern Illinois.