Youssef Chami, MD

Associate Professor, Program Director, Cardiovascular Fellowship Program; Chief, Division of Cardiology, Vice Chair, Department of Internal Medicine
Internal Medicine

    About me

    Gender

    Male

    Languages spoken

    Arabic,
    French

    Education & training

    Positions
    Cardiologist
    Board Certifications
    Interventional Cardiology
    Cardiovascular Disease
    Internal Medicine
    Medical School
    Claude Bernard University, Lyon, France - 1983
    Undergraduate Degree
    Lycee Francais (Mission Laique Francaise), Beirut, Lebanon - 1975
    Residency
    Internal Medicine, University of Montreal, Notre Dame Hospital, Montreal Canada - 1983
    Internal Medicine and Cardiology, Hospital Cardjologigue, Lyon, France - 1983
    Internship, Rotating, Hospital Du Vinatier, Lyon, France - 1982
    Fellowship
    University of Montreal, Montreal Heart Institute - Cardiology
    Medical College of Virginia - Interventional Cardiology

    Publications

    Poster Presentation(s):

    September 1993 is" Congress of the European Society of Cardiology; Nice, France "Angioscopicand Angiographic Characteristics of Restenotic and De Novo Lesions Prior and After CatheterIntervention"

    Abstracts

    1. Gagnon RM, Chami YG, Morissette M, Guerard MJ: Endomyocardial Biopsy: Our experience and review of the literature. Hospital Notre Dame Scientific Session,1986.

    2. Goudreau E, Warner M, DiSciascio G, Cowley MJ, Chami YG, Kelly K, Kohli R, Sabri N, Vetrovec GW: Can late restenosis be predicted by lesion changes following successful PTCA? Clin. Res. 38:964A, 1990.

    3. Goudreau E, DiSciascio G, Vetrovec G, Chami YG, Warner M, Sabri N, Kohli R, Cowley MJ: Effectiveness of intracoronary urokinase as adjunct to coronary angioplasty in patients with complex lesion morphology or angioplasty induced complications. XIII Congress of Cardiology, Amsterdam, 1991.

    4. Gilmore P, Bass T, Conetta D, Peterson K, McDonald M, Chami YG, Buchbinder M: Coronary intravascular ultrasound delineation of elastic recoil following balloon angioplasty and absence of recoil following balloon angioplasty and absence of recoil following rotational atherectomy.

    5. Bass TA, Gilmore P, White C, Chami YG, Kircher B, Conetta D: Morphological differences in coronary arteries following rotational atherectomy versus balloon
      angioplasty: Ultrasound and angioscopic observations. Presented Biomedical Optics Society, SPIE, Los Angeles, California, January 1993.

    6. Bass TA, Kelsey RC, Chami YG, Koenig M, Gilmore PS: Balloon angioplasty compliance ultrasound study - results of the Bacus Trial. The Society for Cardiac
      Angiography and Interventions. May 1996

    7. Sekosan M, Blanchard J, Massad J, Lutrin F, Dunn T, Raofi V, Chami YG, Holman D, Nawas S, Benedetti E: Correlation of cardiac and skeletal muscle allograft rejection in a non-immunosuppressed rat model. International Society for Heart and Lung Transplantation is" Annual Meeting.

    8. Buenvenida C, Tiongco F, Chami YG, Benedetti E, Tejpal YT, Wiley T, Layden T, Massad M: Use of 2-D echo and right heart catheterization for diagnosis of
      pulmonary hypertension in patients evaluated for liver transplantation. Transplantation 1998; 65(8): 101.

    9. Tiongco F, Buenvenida C, Chami YG, Benedetti E, Massad M, Tejpal Y, Wiley T, Layden T: The use of echocardiography and right heart catheterization in the diagnosis of pulmonary hypertention in patients undergoing liver transplantation. American Gastroenterological Society May 1998.

    Papers and Book Chapters

    1. Chami YG, Robert JM, David L: 49XYYYY Syndrome. Review of Literature (Submitted for Publication)

    2. Warner M, Chami YG, Johnson D, Cowley M: Salvage Coronary atherectomy in the setting for failure PTCA. Catheterization and Cardiovasc Diag 1991; 24: 28-31

    3. Goudreau E, SiSciasscio G, Vetrovee GW, Chami YG, Warner M, Nath A, Kohli RS, Sabri N, Cowley MJ: Intracoronary urokinase as an adjunct to Percutaneous transluminal coronary angioplasty in patients with complex lesion morphology or angioplasty induced complications. American Journal of Cardiology. 1992; 69:57-62

    4. Gilmore P, Chami YG: Transcatheter coronary interventional techniques. New Device Case Studies. Jacksonville Medicine1992; 43(1): 16-20

    5. Gilmore P, Bass T, Miller AB, Chami YG: High speed rotational coronary atherectomy. The Florida Experience. Clin-Cardiol. 1993; April 16(4): 311-6.

    6. Sanchez-Ramos L, Chami YG, Bass TA, Del Vaile GO, Adair CD: Myocardial infarction during pregnancy: Management with transluminal coronary angioplasty and metallic intracoronary stents. American Journal of Obstet - Gynecol. 1994 171(5): 1392-1393

    7. EPIC Investigators (Chami YG – Co-Investigator): Use of a monoclonal antibody directed against the patient glycoprotein lib/ilia receptor in high risk coronary
      angioplasty. New England Journal of Medicine. April 7, 1994 (330): 956-961

    8. DiDomenico RJ, Chami YG, Bauman JL: Unstable angina pectoris associated with phentermine in a patient with known coronary disease. Journal for Appfied
      Therapeutics.
      1997; 2: 63-67.

    9. Podbielski FJ, O'Leary P, Chami YG, Massad M: What makes a coronary myocardial bridge symptomatic? Minerva Cardioangiologia 1998; 46(4): 127-30

    10. Massad M, Benedetti E, Pollak R, Chami YG, Allen BS, DeCastro MA, Wiley T, Layden TJ: Combined coronary bypass and orthotopic liver transplantation: Technical considerations. Ann Thorac Surg. 1998; 54(4): 1130-2.

    11. Buenvenida C, Tiongco F, Chami YG, Benedetti E, Tejpal V, Wiley T, Layden T, Massad M: Use of 2-D echo and right heart catheterization for diagnosis of pulmonary hypertension in patients evaluated for liver transplantation. Transplantation 1998; 65(8): 101.

    12. PURSUIT Trial Investigators (Chami YG-Site Principal Investigator): Inhibition of platelet glycoprotein lib/ilia with eptifibatide in patients with acute coronary
      syndromes. New England Journal of Medicine. 1998; 339: 436-443

    13. Rochon B, Chami Y, Sachdeva R, Bissett JK, Willis N, Uretsky BR. Mannual aspiration thrombectomy in acute ST elevation myocardial infarction. New gold standard. World J cardio 2011, Feb 26, 3 (2):43 – 7.

    14. Ghassibe-Sabbagh, M., Deeb, M., Salloum, A.K., Mouzaya, F., Haber, M., Al-Sarraj, Y., Chami, Y., Akle, Y., Hirbli, K., Nemr, R., Ahdab, R., Platt, D.E., Abchee, A.B., El-Shanti, H., Zalloua,P.A. Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population (2014) Diabetology and Metabolic Syndrome, 6 (1), art. no. 89.

    15. Merhi M, Demirdjian S, Hariri E, Sabbah N, You hanna S, Ghassibe-Sabbagh M, Naoum J, Haber M, Othman R. Kibbani S, Chammas E, Kanbar R, Bayeh HE, Chami YG, Abchee A, Platt DE, Zalloua P, Khazen G:Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk. Inflamm Res, 2015 Apr 24.

    16.  Milane, A., Khazen, G., Zeineddine, N., Amro, M., Masri, L., Ghassibe-Sabbagh, M., Youhanna, S., Salloum, A.K., Haber, M., Platt, D.E., Cazier, J.-B., Othman, R., Kabbani, S., Sbeite, H., Chami, Y., Chammas, E., el Bayeh, H., Gauguier, D., Abchee, A.B., Zalloua, P., Barbari, A .Association of coronary artery disease and chronic kidney disease in Lebanese population (2015) International Journal of Clinical and Experimental Medicine, 8 (9), pp. 15866-15877.

    Grants

    Site Principal Investigator:

    2000-2001            Senior PAMI
    1999-2000            PRAISE II Trial
    1999-2000            ESPRIT Trial
    1999-2000            Cachet Trial
    1998-1998            ASSENT II Trial
    1997-1999            SYMPHONY Trial
    1996-1997            PURSUIT Trial (IL 057)
     

    Site Co-Investigators:

    Grant from the Medicines Company. "A clinical trial comparing treatment with cangrelor (in combination with usual care) to usual care, in subjects who require percutaneious coronary intervention." Conducted: 2008-Present

    Grant from Genentech, Inc: "A Randomized Trial Evaluating Low-Dose IntraCoronary Adjunctive Tenecteplase During Primary PCI for ST-Elevation Myocardial Infarction." Conducted: 2008-Present

    Grant from CardioMems. "Cardiomems heart sensor allows monitoring of pressure to improve outcomes in NYHA class III heart failure patients." Conducted: 2008-Present

    Grant from Abbott Vascular Devices. "Emboshield and Xact Post Approval Carotid Stent Trial using the Ernoshield" BareWire® Rapid Exchange Embolic and Xact" Rapid Exchange Carotid Stent System." Conducted: 2006-Present

    Grant from GlaxoSmithKline. "An Open, Nonrandomized Comparison of Pharmacokinetic Profiles of Carvedilol (SK&F-105517) MR and IR on Repeat Dosing in Chronic CHF Patients and Survivors of an Acute MI and LVD./I Conducted: 2005

    Grant from Sterotaxis. "Interventional Cardiology Prospective Data and Analysis for Conventional Cases." Conducted: 2005-2006

    Grant from Schering-Plough Research Institue: "A Multicenter, Double-Blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin Monotherapy in High-Rish Subjects Presenting with Acute Coronary Syndrome." Conducted: 2005-Present

    Grant from Novartis Pharmaceuticals. "A 6-week, multicenter, randomized, double-blind, parallel-group study to evaluate the combination of valsartan/HCTZ (160/12.5 mg with forced titration to a maximum dose of 320/25 mg) compared to valsartan monotherapy (160 mg with forced titration to 320 mg) as initial therapy in patients with severe hypertension." Conducted: 2005-Present

    Grant from Lilly Research Institute. "A Comparison of CS-747 and Clopidogrel in acute coronary syndrome subjects who are undergo percutaneous coronary intercention-TIMI 38." Conducted: 2005-Present

    Grant from Cordis. "DEScover Registry Protocol." Conducted: 2005-Present

    Grant from the Medicines Company. "A trial fibrillation Clopidogrel Trials with Irbesartan for prevention of Vascular Events - ACTIVE, A parallel randomized controlled evaluation of clopidogrel plus aspirin, with factorial evaluation of Irbesartan for prevention of vascular events, in patients with atrial fibrillation (EFC4912)." Conducted: 2004-Present

    Grant from Sanofi-Aventis. "Atrial fibrillation Clopidogrel Trials with Irbesartan for prevention of Vascular Events - ACTIVE, A parallel randomized controlled evaluation of clopidogrel plus aspirin, with factorial evaluation of Irbesartan, for the prevention of vascular events, in patients with atrial fibrillation (EFC4912)." Conducted: 2004-Present

    Grant from Guidant. "Carotid RX ACCULINK/ACCUNET Post Approval Trial to Uncover Unanticipated of Rare Events." Conducted 2004-Present

    Grant from Centocor: "A multicenter, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of Reteplase and Abeiximab combination therapy with Abeiximab alone administered early or just prior to Primary Percutaneious Coronary Intervention for Acute Myocardiallnfaraction (FINESSE: Protocol No. COl16T40)." Conducted: 2004

    Grant from Medtronic. "A Multicenter, Non-inferiority Randomized, Controlled Trial to Evaluate the Safety and Efficacy of the Medtronic AVE interceptor' Coronary Filter System in Subjects with DE NOVO and Restenotic Lesions of Saphenous Vein Grafts." Conducted: 2004

    Grant from Spectronectics. "Coronary graft results following atherectomy with laser." Conducted: 2004-2005

    Grant from Possis Medical Inc. "AngioJet Rheolytic Thrombectomy in Patients Undergoing Primary Angioplasty for Acute Mvocardtal tnfarctlon." Conducted: 2003-2005

    Grant from Aventis Pharmaceutical, Inc. "Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment" Conducted: 20003-2005

    Grant from Theragenics. itA Safety and Feasibility Study of Use of the Terasource' Intravascular Brachytherapy System for Prevention of Restenosis Following Successful Percutaneoua Transluminal Angioplasty (PTA) in the Superficial Femoral and Popliteal Arteries." Conducted 2003-2004

    Grant from Millennium Pharmaceuticals, Inc. "A randomized trial to evaluate the relative protection against post-PCI microvascular dysfunction and post-PCI ischemia among anti-platelet and anti-thrombotic agents." Conducted: 2003-2004

    Aggrastat to Zocor Study: A multicenter, randomized, controlled, double-blind trial to investigate the clinical efficacy and tolerability of early treatment with Simvastatin 40mg daily for 30 Days, followed by Simvastatin 80mg daily thereafter in Tirofiban treated Acute Coronary Syndrome patients who have been randomized to receive Enoxaparin or Unfractionated Heparin in conjunction with Aspirin. Conducted: 2001-2002

    CARISA - Conducted: 2000-2001
    PYRAMID - Conducted: 2000-2001
    Heartbar (effect of Oral Nutrient Supplementation on Exercise Tolerance in patients with Stable Coronary Disease) Conducted: 2000-2001
    STEPAMI2 - Conducted: 2000-2001
    EPIC Trial - Conducted: 1992-1993
    QUIET Trial - Conducted: 1991-1994


     

    Clinical trials

    Trial
    Cardiothoracic Surgery

    Clinical Study of the BioVentrix TC System for the Treatment of Left Ventricular Aneurysm

    Active recruiting

    The purpose of the study is to demonstrate the safety and effectiveness of the BioVentrix Revivent TC System for the treatment of LV antero-septal aneurysms/scars in patients with symptomatic heart failure.