Andrea Braundmeier-Fleming, PhD
Dr. Andrea Braundmeier-Fleming is an Assistant Professor in the Department of Medical Microbiology, Immunology and Cell Biology and an Adjunct Assistant Professor in the Department of Obstetrics and Gynecology at Southern Illinois University School of Medicine.
The immune system plays a significant role in reproductive processes such as embryonic implantation and fetal development but also in reproductive diseases and disorders. The overall goals of my research are to: 1) Understand the mechanisms of maternal immune suppression during early pregnancy, 2) Understand the regulation of immune cells in the development of gynecological and obstetrical conditions (ie. endometriosis, preeclampsia, and intra-uterine growth restriction), 3) Identify microbial communities and shifts in these communities with reproductive disorders and 4) Utilizing nutritional intervention to treat reproductive disorders. Investigating the biocomplexity and communication between our immune, microbial and reproductive systems will translate into the development of complementary and alternative therapies for treatment of reproductive disorders. Research topics that I am currently developing are:
- Dysregulation of immune cells in the onset of preterm birth.
- Immune suppression in the development of ectopic endometrial lesions.
- Modifying immune cell populations through probiotic and nutritional supplementation to enhance pre- and post-natal fetal development.
- The identification of the microbiome profiles of reproductive disorders.
Utilizing biomedical animal models, multi- disciplinary investigational approaches and current molecular and cellular biological techniques, I believe that knowledge gained from these proposals can quickly be translated and implemented into human and animal medicine.
Molecular and Cellular Biological Techniques
- Immune Cell Proliferation Assays
- Quantitative PCR
- 16S and Metagenomic Bacterial Sequencing
- Mammalian Cell Culture
- RNA interference
- Microbiome Bioinformatics
Utilizing the microbiome to diagnose preterm birth. AG. Braundmeier (PI). SIUSOM-RSG.