Keith Hruska, MD

1. Stein PD, Folkens AT, Hruska KA. Saccharomyces fungemia. Chest.
1970;58(2):173-5. PMID:5455300
2. Rutherford E, Mercado A, Hruska KA, Harter H, Mason N, Sparks R, Klahr S,
Slatopolsky E. An evaluation of a new and effective phosphate binding
agent. Trans ASAIO. 1973;XIX.
3. Rutherford WE, Hruska K, Blondin J, Holick M, DeLuca H, Klahr S,
Slatopolsky E. The effect of 5,6-trans vitamin D3 on calcium absorption in
chronic renal disease. J Clin Endocrinol Metab. 1975;40(1):13-
18. doi:10.1210/jcem-40-1-13 PMID:1112871
4. Hruska K, Kopelman R, Rutherford WE, Greenwalt A, Klahr S, Slatopolsky E.
Parathyroid hormone (PTH) metabolism in chronic renal disease (CRD). Proc
Eur Dial Transplant Assoc. 1975;11:457-64. PMID:1197270
5. Hruska KA, Kopelman R, Rutherford WE, Klahr S, Slatopolsky E, Greenwalt
A, Bascom T, Markham J. Metabolism in immunoreactive parathyroid
hormone in the dog. The role of the kidney and the effects of chronic renal
disease. J Clin Invest. 1975;56(1):39-
48. doi:10.1172/JCI108077 PMCID:PMC436553 PMID:1141439
6. Rutherford WE, Blondin J, Hruska K, Kopelman R, Klahr S, Slatopolsky E.
Effect of 25-hydroxycholecalciferol on calcium absorption in chronic renal
disease. Kidney Int. 1975;8(5):320-4. PMID:1195563
7. Martin K, Hruska K, Greenwalt A, Klahr S, Slatopolsky E. Selective uptake of
intact parathyroid hormone by the liver: differences between hepatic and
renal uptake. J Clin Invest. 1976;58(4):781-
8. doi:10.1172/JCI108529 PMCID:PMC333239 PMID:965485
8. Rutherford WE, Bordier P, Marie P, Hruska K, Harter H, Greenwalt A,
Blondin J, Haddad J, Bricker N, Slatopolsky E. Phosphate control and 25-
hydroxycholecalciferol administration in preventing experimental renal
osteodystrophy in the dog. J Clin Invest. 1977;60(2):332-
41. doi:10.1172/JCI108781 PMCID:PMC372373 PMID:874095
9. Hruska KA, Martin K, Mennes P, Greenwalt A, Anderson C, Klahr S,
Slatopolsky E. Degradation of parathyroid hormone and fragment production
by the isolated perfused dog kidney. The effect of glomerular filtration rate
and perfusate CA++ concentrations. J Clin Invest. 1977;60(3):501-
10. doi:10.1172/JCI108802 PMCID:PMC372395 PMID:893661
10. Anderson CB, Haid SD, Hruska KA, Etheredge EE. Adverse effect of
ischemic companion kidney during ex vivo renal perfusion. Transplant Proc.
1977;9(3):1625-7. PMID:331601
11. Martin KJ, Hruska KA, Lewis J, Anderson C, Slatopolsky E. The renal
handling of parathyroid hormone. Role of peritubular uptake and glomerular
filtration. J Clin Invest. 1977;60(4):808-
14. doi:10.1172/JCI108834 PMCID:PMC372428 PMID:893678
12. Teitelbaum SL, Hruska KA, Shieber W, Debnam JW, Nichols SH.
Tetracycline fluorescence in uremic and primary hyperparathyroid bone.
Kidney Int. 1977;12(5):366-72. PMID:604625
13. Martin KJ, Freitag JJ, Conrades MB, Hruska K, Klahr S, Slatopolsky E. The
uptake of parathyroid hormone by isolated perfused bone: possible
significance of peripheral hormone metabolism. Trans Assoc Am Physicians.
1978;91:358-67. PMID:224552
14. Anderson CB, Haid SD, Hruska KA, Etheredge EE. Renal injury by
companion kidney during hypothermic pulsatile perfusion. Surgery.
1978;83(1):72-7. PMID:619474
15. Freitag J, Martin KJ, Hruska KA, Anderson C, Conrades M, Ladenson J,
Klahr S, Slatopolsky E. Impaired parathyroid hormone metabolism in patients
with chronic renal failure. N Engl J Med. 1978;298(1):29-
32. doi:10.1056/NEJM197801052980107 PMID:337145
16. Anderson CB, Haid SD, Hruska KA, Etheredge EA. Significance of microbial
contamination of stored cadaver kidneys. Arch Surg. 1978;113(3):269-
71. PMID:25059
17. Slatopolsky E, Gray R, Adams ND, Lewis J, Hruska K, Martin K, Klahr S,
DeLuca HF, Lehmann J. Low levels of 1,25(OH)2D3 are not responsible for
the development of secondary hyperparathyroidism in early renal failure. Kid
Int. 1978;14:S733.
18. Slatopolsky E, Rutherford WE, Hruska K, Martin K, Klahr S. How important is
phosphate in the pathogenesis of renal osteodystrophy? Arch Intern Med.
1978;138 Spec No:848-52. PMID:646572
19. Hruska, K.A., Teitelbaum, S.L., Kopelman, R., Richardson, C.A., Miller, P.,
Debman, J., Martin, K., Slatopolsky, E. The predictability of the histologic al
features of uremic bone disease by non-invasive techniques. Metab Bone
Dis & Rel Res. 1978;1:39-44.
20. Martin KJ, Freitag JJ, Conrades MB, Hruska KA, Klahr S, Slatopolsky E.
Selective uptake of the synthetic amino terminal fragment of bovine
parathyroid hormone by isolated perfused bone. J Clin Invest.
1978;62(2):256-
61. doi:10.1172/JCI109124 PMCID:PMC371761 PMID:209059
21. Molitoris BA, Hruska KA, Fishman N, Daughaday WH. Effects of glucose and
parathyroid hormone on the renal handling of myoinositol by isolated
perfused dog kidneys. J Clin Invest. 1979;63(6):1110-
8. doi:10.1172/JCI109403 PMCID:PMC372057 PMID:221533
22. Peterson LJ, Hruska KA. The benefits of evaluation of the patient with
recurrent or multiple calcium stones. J Urol. 1979;121(6):766-
8. PMID:458948
23. Rosenbaum RW, Hruska KA, Anderson C, Robson AM, Slatopolsky E, Klahr
S. Inulin: an inadequate marker of glomerular filtration rate in kidney donors
and transplant recipients? Kidney Int. 1979;16(2):179-86. PMID:390219
24. Hruska KA, Blondin J, Bass R, Santiago J, Thomas L, Altsheler P, Martin K,
Klahr S. Effect of intact parathyroid hormone on hepatic glucose release in
the dog. J Clin Invest. 1979;64(4):1016-
23. doi:10.1172/JCI109538 PMCID:PMC372211 PMID:479365
25. Martin KJ, Hruska KA, Freitag JJ, Klahr S, Slatopolsky E. The peripheral
metabolism of parathyroid hormone. N Engl J Med. 1979;301(20):1092-
8. doi:10.1056/NEJM197911153012005 PMID:386126
26. Martin KJ, Hruska K, Freitag J, Bellorin-Font E, Klahr S, Slatopolsky E. The
clinical utility of radioimmunoassays for parathyroid hormone. Min Electrol
Metab. 1980;3:283.
27. Teitelbaum SL, Bergfeld MA, Freitag J, Hruska KA, Slatopolsky E. Do
parathyroid hormone and 1,25-dithydroxyvitamin D modulate bone formation
in uremia? J Clin Endocrinol Metab. 1980;51(2):247-51. doi:10.1210/jcem-
51-2-247 PMID:6893204
28. Sicard GA, Anderson CB, Hruska KA, Martin KJ, Etheredge EE.
Parathormone levels after subtotal and total (autotransplantation)
parathyroidectomy for secondary hyperparathyroidism. J Surg Res.
1980;29(6):541-5. PMID:7431907
29. Galim EB, Hruska K, Bier DM, Matthews DE, Haymond MW. Branched-chain
amino acid nitrogen transfer to alamine in vivo in dogs. Direct isotopic
determination with [15N]leucine. J Clin Invest. 1980;66(6):1295-
304. doi:10.1172/JCI109981 PMCID:PMC371614 PMID:7440716
30. Hammerman MR, Karl IE, Hruska KA. Regulation of canine renal vesicle Pi
transport by growth hormone and parathyroid hormone. Biochim Biophys
Acta. 1980;603(2):322-35. PMID:7459358
31. Slatopolsky E, Martin K, Morrissey J, Hruska, K. Current concepts of the
metabolism and radioimmunoassay of parathyroid hormone. Semin Nephrol.
1981;1:319-334.
32. Hruska KA, Korkor A, Martin K, Slatopolsky E. Peripheral metabolism of
intact parathyroid hormone. Role of liver and kidney and the effect of chronic
renal failure. J Clin Invest. 1981;67(3):885-
92. PMCID:PMC370640 PMID:7204561
33. Rosenbaum RW, Hruska KA, Korkor A, Anderson C, Slatopolsky E.
Decreased phosphate reabsorption after renal transplantation: Evidence for
a mechanism independent of calcium and parathyroid hormone. Kidney Int.
1981;19(4):568-78. PMID:6264200
34. Hruska KA, Hammerman MR. Parathyroid hormone inhibition of phosphate
transport in renal brush border vesicles from phosphate-depleted dogs.
Biochim Biophys Acta. 1981;645(2):351-6. PMID:7272293
35. Klahr S, Morrissey J, Hruska K. Effect of parathyroid hormone on
phospholipid metabolism. Adv Exp Med Biol. 1982;151:561-
75. PMID:6758524
36. Martin KJ, Hruska K, Tamayo J, Arbelaez M, Slatopolsky E. Hepatic
metabolism of parathyroid hormone. Miner Electrolyte Metab. 1982;8(3-
4):173-8. PMID:7167132
37. Martin K, Hruska K, Slatopolsky E. Interactions between liver and parathyroid
hormone. Adv Exp Med Biol. 1982;151:597-605. PMID:7180665
38. Hruska KA, Klahr S, Hammerman MR. Decreased luminal membrane
transport of phosphate in chronic renal failure. Am J Physiol.
1982;242(1):F17-22. PMID:7058889
39. Hammerman MR, Hruska KA. Cyclic AMP-dependent protein
phosphorylation in canine renal brush-border membrane vesicles is
associated with decreased phosphate transport. J Biol Chem.
1982;257(2):992-9. PMID:6274874
40. Cohen MA, Hruska KA, Daughaday WH. Free myo-inositol in canine kidneys:
selective concentration in the renal medulla. Proc Soc Exp Biol Med.
1982;169(3):380-5. PMID:7063520
41. Slatopolsky E, Martin K, Morrissey J, Hruska K. Current concepts of the
metabolism and radioimmunoassay of parathyroid hormone. J Lab Clin Med.
1982;99(3):309-16. PMID:7057058
42. Weinreb S, Hruska KA, Klahr S, Hammerman MR. Uptake of Pi in brush
border vesicles after release of unilateral ureteral obstruction. Am J Physiol.
1982;243(1):F29-35. PMID:7046473
43. Meltzer V, Weinreb S, Bellorin-Font E, Hruska KA. Parathyroid hormone
stimulation of renal phosphoinositide metabolism is a cyclic nucleotideindependent
effect. Biochim Biophys Acta. 1982;712(2):258-
67. PMID:6289907
44. Cohn DE, Hruska KA, Klahr S, Hammerman MR. Increased Na+-H+
exchange in brush border vesicles from dogs with renal failure. Am J Physiol.
1982;243(3):F293-9. PMID:7114259
45. Hruska KA, Ban D, Avioli LV. Renal tubular acidosis. Arch Intern Med.
1982;142(10):1909-13. PMID:7125772
46. Hruska KA, Mills SC, Khalifa S, Hammerman MR. Phosphorylation of renal
brush-border membrane vesicles. Effect on calcium uptake and membrane
content of polyphosphoinositides. J Biol Chem. 1983;258(4):2501-
7. PMID:6296149
47. Khalifa S, Mills S, Hruska KA. Stimulation of calcium uptake by parathyroid
hormone in renal brush-border membrane vesicles. Relationship to
membrane phosphorylation. J Biol Chem. 1983;258(23):14400-
6. PMID:6643490
48. Hruska KA, Khalifa S, Meltzer V, Martin K. Calcium as a mediator of the
physiological and pathophysiological effects of parathyroid hormone. Semin
Nephrol. 1984;4:159-173.
49. Kurnik BR, Hruska KA. Effects of 1,25-dihydroxycholecalciferol on phosphate
transport in vitamin D-deprived rats. Am J Physiol. 1984;247(1 Pt 2):F177-
84. PMID:6331201
50. Pohlman T, Hruska KA, Menon M. Renal tubular acidosis. J Urol.
1984;132(3):431-6. PMID:6471171
51. Scoble JE, Mills S, Hruska KA. Calcium transport in canine renal basolateral
membrane vesicles. Effects of parathyroid hormone. J Clin Invest.
1985;75(4):1096-
105. doi:10.1172/JCI111803 PMCID:PMC425432 PMID:3988932
52. Tsutsumi M, Alvarez U, Avioli LV, Hruska KA. Effect of 1,25-dihydroxyvitamin
D3 on phospholipid composition of rat renal brush border membrane. Am J
Physiol. 1985;249(1 Pt 2):F117-23. PMID:3839347
53. Kurnik BR, Hruska KA. Mechanism of stimulation of renal phosphate
transport by 1,25-dihydroxycholecalciferol. Biochim Biophys Acta.
1985;817(1):42-50. PMID:3839137
54. Goligorsky MS, Menton DN, Hruska KA. Parathyroid hormone-induced
changes of the brush border topography and cytoskeleton in cultured renal
proximal tubular cells. J Membr Biol. 1986;92(2):151-62. PMID:3761360
55. Goligorsky MS, Hruska KA. Transcytosis in cultured proximal tubular cells. J
Membr Biol. 1986;93(3):237-47. PMID:3820280
56. Scoble JE, Moskowitz D, Hruska KA. Dibutryladenosine 3',5'-cyclic
monophosphate (dBcAMP) does not mimic the action of parathyroid
hormone (PTH) on canine proximal tubular basolateral membrane
Na+:Ca2+. Adv Exp Med Biol. 1986;208:537-41. PMID:3031954
57. Bar-Shavit R, Hruska KA, Kahn AJ, Wilner GD. Hormone-like activity of
human thrombin. Ann N Y Acad Sci. 1986;485:335-48. PMID:3032049
58. Kurnik BR, Huskey M, Hruska KA. The direct effect of 1,25-
dihydroxycholecalciferol on membrane phospholipid composition and
phosphate transport. Adv Exp Med Biol. 1986;208:115-24. PMID:3565143
59. Shayman JA, Hruska KA, Morrison AR. Bradykinin stimulates increased
intracellular calcium in papillary collecting tubules of the rabbit. Biochem
Biophys Res Commun. 1986;134(1):299-304. PMID:3080988
60. Delmez JA, Fallon MD, Harter HR, Hruska KA, Slatopolsky E, Teitelbaum
SL. Does strict phosphorus control precipitate renal osteomalacia? J Clin
Endocrinol Metab. 1986;62(4):747-52. doi:10.1210/jcem-62-4-
747 PMID:3949954
61. Kurnik BR, Huskey M, Hagerty D, Hruska KA. Vitamin D metabolites
stimulate phosphatidylcholine transfer to renal brush-border membranes.
Biochim Biophys Acta. 1986;858(1):47-55. PMID:3754768
62. Hruska KA, Goligorsky M, Scoble J, Tsutsumi M, Westbrook S, Moskowitz D.
Effects of parathyroid hormone on cytosolic calcium in renal proximal tubular
primary cultures. Am J Physiol. 1986;251(2 Pt 2):F188-98. PMID:3740268
63. Goligorsky MS, Hruska KA, Loftus DJ, Elson EL. Alpha 1-adrenergic
stimulation and cytoplasmic free calcium concentration in cultured renal
proximal tubular cells: evidence for compartmentalization of quin-2 and fura-
2. J Cell Physiol. 1986;128(3):466-
74. doi:10.1002/jcp.1041280316 PMID:3755726
64. Goligorsky MS, Loftus DJ, Hruska KA. Cytoplasmic calcium in individual
proximal tubular cells in culture. Am J Physiol. 1986;251(5 Pt 2):F938-
44. PMID:3777189
65. Hruska KA, Moskowitz D, Esbrit P, Civitelli R, Westbrook S, Huskey M.
Stimulation of inositol trisphosphate and diacylglycerol production in renal
tubular cells by parathyroid hormone. J Clin Invest. 1987;79(1):230-
9. doi:10.1172/JCI112788 PMCID:PMC424029 PMID:3025260
66. Goligorsky MS, Duncan RL, Westbrook S, Reinach P, Hruska KA.
Demonstration of a direct effect of atrial natriuretic factor on epithelium: study
in cultured pig kidney cells. Miner Electrolyte Metab. 1987;13(1):51-
6. PMID:2953957
67. Kurnik BR, Huskey M, Hruska KA. 1,25-Dihydroxycholecalciferol stimulates
renal phosphate transport by directly altering membrane phosphatidylcholine
composition. Biochim Biophys Acta. 1987;917(1):81-5. PMID:3790614
68. Suzuki Y, Fausto A, Hruska KA, Avioli LV. Stimulation of phosphatidylcholine
biosynthesis in diabetic hypertrophic kidneys. Endocrinology.
1987;120(2):595-601. doi:10.1210/endo-120-2-595 PMID:3803292
69. Martin KJ, Finch JL, Hruska K, Slatopolsky E. Effect of biological activity of
PTH on its peripheral metabolism in the rat. Kidney Int. 1987;31(4):937-
40. PMID:3586500
70. Goligorsky MS, Menton DN, Hruska KA. Effects of phorbol ester, cyclic
nucleotides, and ionomycin on ion transport and brush-border topography in
cultured renal proximal tubular cells. Ann NY Acad Sci. 1987;494 :208-210.
71. Reid IR, Civitelli R, Westbrook SL, Avioli LV, Hruska KA. Cytoplasmic pH
regulation in canine renal proximal tubule cells. Kidney Int. 1987;31(5):1113-
20. PMID:3599651
72. Bar-Shavit R, Hruska KA, Kahn AJ, Wilner GD. Thrombin chemotactic
stimulation of HL-60 cells: studies on thrombin responsiveness as a function
of differentiation. J Cell Physiol. 1987;131(2):255-
61. doi:10.1002/jcp.1041310216 PMID:3034923
73. Civitelli R, Reid IR, Halstead LR, Avioli LV, Hruska KA. Membrane potential
and cation content of osteoblast-like cells (UMR 106) assessed by
fluorescent dyes. J Cell Physiol. 1987;131(3):434-
41. doi:10.1002/jcp.1041310316 PMID:3474236
74. Reid IR, Civitelli R, Halstead LR, Avioli LV, Hruska KA. Parathyroid hormone
acutely elevates intracellular calcium in osteoblastlike cells. Am J Physiol.
1987;253(1 Pt 1):E45-51. PMID:3037917
75. Hruska KA. Regulation of renal phosphate reabsorption: concepts in
evolution. Pediatr Nephrol. 1987;1(4):657-63. PMID:3153347
76. Goligorsky MS, Osborne D, Howard T, Hruska KA, Karl IE. Hormonal
regulation of gluconeogenesis in cultured proximal tubular cells: role of
cytosolic calcium. Am J Physiol. 1987;253(5 Pt 2):F802-9. PMID:3688237
77. Goligorsky MS, Hruska KA. Hormonal modulation of cytoplasmic calcium
concentration in renal tubular epithelium. Miner Electrolyte Metab.
1988;14(1):58-70. PMID:3279296
78. Shen V, Hruska K, Avioli LV. Characterization of a (Ca2+ + Mg2+)-ATPase
system in the osteoblast plasma membrane. Bone. 1988;9(5):325-
9. PMID:2974293
79. Reid IR, Civitelli R, Avioli LV, Hruska KA. Parathyroid hormone depresses
cytosolic pH and DNA synthesis in osteoblast-like cells. Am J Physiol.
1988;255(1 Pt 1):E9-15. PMID:2839040
80. Filipponi P, Mannarelli C, Pacifici R, Grossi E, Moretti I, Tini S, Carloni C,
Blass A, Morucci P, Hruska KA. Evidence for a prostaglandin-mediated bone
resorptive mechanism in subjects with fasting hypercalciuria. Calcif Tissue
Int. 1988;43(2):61-6. PMID:3142668
81. Scoble JE, Cragoe EJ Jr, Hruska KA. Na+-Ca2+ exchange and calcium
permeability in canine basolateral membrane vesicles: the effects of dibutyryl
cAMP and specific inhibitors. Biochim Biophys Acta. 1988;944(2):233-
41. PMID:2846057
82. Civitelli R, Reid IR, Westbrook S, Avioli LV, Hruska KA. PTH elevates inositol
polyphosphates and diacylglycerol in a rat osteoblast-like cell line. Am J
Physiol. 1988;255(5 Pt 1):E660-7. PMID:3263806
83. Hruska KA, Bar-Shavit Z, Malone JD, Teitelbaum S. Ca2+ priming during
vitamin D-induced monocytic differentiation of a human leukemia cell line. J
Biol Chem. 1988;263(31):16039-44. PMID:3182781
84. Suzuki Y, Hruska KA, Reid I, Alvarez UM, Avioli LV. Characterization of
phospholipase C activity of the plasma membrane and cytosol of an
osteoblast-like cell line. Am J Med Sci. 1989;297(3):135-44. PMID:2923133
85. Greenwald JE, Apkon M, Hruska KA, Needleman P. Stretch-induced
atriopeptin secretion in the isolated rat myocyte and its negative modulation
by calcium. J Clin Invest. 1989;83(3):1061-
5. doi:10.1172/JCI113948 PMCID:PMC303784 PMID:2522102
86. Civitelli R, Hruska KA, Jeffrey JJ, Kahn AJ, Avioli LV, Partridge NC. Second
messenger signaling in the regulation of collagenase production by
osteogenic sarcoma cells. Endocrinology. 1989;124(6):2928-
34. doi:10.1210/endo-124-6-2928 PMID:2542004
87. Karpinski E, Wu L, Civitelli R, Avioli LV, Hruska KA, Pang PK. A
dihydropyridine-sensitive calcium channel in rodent osteoblastic cells. Calcif
Tissue Int. 1989;45(1):54-7. PMID:2548684
88. Teti A, Grano M, Teitelbaum SL, Hruska KA, Colucci S, Zambonin Zallone A.
Regulation of podosomes by intracellular pH in avian osteoclasts. Boll Soc
Ital Biol Sper. 1989;65(7):597-601. PMID:2597415
89. Teti A, Grano M, Teitelbaum SL, Hruska KA, Colucci S, Zambonin Zallone A.
Intracellular acidification induces decrease of cytosolic calcium in isolated
osteoclasts. Boll Soc Ital Biol Sper. 1989;65(8):689-93. PMID:2803732
90. Teti A, Blair HC, Schlesinger P, Grano M, Zambonin-Zallone A, Kahn AJ,
Teitelbaum SL, Hruska KA. Extracellular protons acidify osteoclasts, reduce
cytosolic calcium, and promote expression of cell-matrix attachment
structures. J Clin Invest. 1989;84(3):773-
80. doi:10.1172/JCI114235 PMCID:PMC329718 PMID:2547838
91. Civitelli R, Martin TJ, Fausto A, Gunsten SL, Hruska KA, Avioli LV.
Parathyroid hormone-related peptide transiently increases cytosolic calcium
in osteoblast-like cells: comparison with parathyroid hormone. Endocrinology.
1989;125(3):1204-10. doi:10.1210/endo-125-3-1204 PMID:2503365
92. Teti A, Barattolo R, Grano M, Colucci S, Argentino L, Teitelbaum SL, Hruska
KA, Santacroce G, Zambonin Zallone A. Podosome expression in
osteoclasts: influence of high extracellular calcium concentration. Boll Soc
Ital Biol Sper. 1989;65(11):1039-43. PMID:2629823
93. Teti A, Grano M, Colucci S, Argentino L, Barattolo R, Miyauchi A, Teitelbaum
SL, Hruska KA, Zambonin Zallone A. Voltage dependent calcium channel
expression in isolated osteoclasts. Boll Soc Ital Biol Sper. 1989;65(12):1115-
8. PMID:2560636
94. Civitelli R, Teitelbaum SL, Hruska KA, Lacey DL. IL-1 activates the Na+/H+
antiport in a murine T cell. J Immunol. 1989;143(12):4000-8. PMID:2556473
95. Civitelli R, Hruska KA, Shen V, Avioli LV. Cyclic AMP-dependent and
calcium-dependent signals in parathyroid hormone function. Exp Gerontol.
1990;25(3-4):223-31. PMID:2171968
96. Teitelbaum SL, Hruska KA. 1,25-Dihydroxycholecalciferol and macrophage
differentiation with aging. Exp Gerontol. 1990;25(3-4):233-8. PMID:2171969
97. Dunlay R, Hruska K. PTH receptor coupling to phospholipase C is an
alternate pathway of signal transduction in bone and kidney. Am J Physiol.
1990;258(2 Pt 2):F223-31. PMID:2155534
98. Pacifici R, Rothstein M, Rifas L, Lau KH, Baylink DJ, Avioli LV, Hruska K.
Increased monocyte interleukin-1 activity and decreased vertebral bone
density in patients with fasting idiopathic hypercalciuria. J Clin Endocrinol
Metab. 1990;71(1):138-45. doi:10.1210/jcem-71-1-138 PMID:2370292
99. Gupta A, Hruska KA, Wedner HJ. Phytohemagglutinin rapidly lyses S49 Tlymphoma
cells and the cytotoxicity is not mediated by generation of cAMP
or increase in cytosolic calcium. Biochem Biophys Res Commun.
1990;170(3):1035-43. PMID:2167667
100. Miyauchi A, Dobre V, Rickmeyer M, Cole J, Forte L, Hruska KA. Stimulation
of transient elevations in cytosolic Ca2+ is related to inhibition of Pi transport
in OK cells. Am J Physiol. 1990;259(3 Pt 2):F485-93. PMID:2396674
101. Civitelli R, Kim YS, Gunsten SL, Fujimori A, Huskey M, Avioli LV, Hruska KA.
Nongenomic activation of the calcium message system by vitamin D
metabolites in osteoblast-like cells. Endocrinology. 1990;127(5):2253-
62. doi:10.1210/endo-127-5-2253 PMID:2226314
102. Miyauchi A, Hruska KA, Greenfield EM, Duncan R, Alvarez J, Barattolo R,
Colucci S, Zambonin-Zallone A, Teitelbaum SL, Teti A. Osteoclast cytosolic
calcium, regulated by voltage-gated calcium channels and extracellular
calcium, controls podosome assembly and bone resorption. J Cell Biol.
1990;111(6 Pt 1):2543-52. PMCID:PMC2116358 PMID:1703539
103. Rothstein M, Obialo C, Hruska KA. Renal tubular acidosis. Endocrinol Metab
Clin North Am. 1990;19(4):869-87. PMID:2081516
104. Hruska KA, Civitelli R, Duncan R, Avioli LV. Regulation of skeletal
remodeling by parathyroid hormone. Contrib Nephrol. 1991;91:38-
42. PMID:1800010
105. Civitelli R, Hruska KA. Monitoring cytosolic calcium in renal epithelia. Special
issue "Methods in Kidney Epithelial Cell Culture" J Tiss Cul Methods.
1991;13:217-228.
106. Gupta A, Martin KJ, Miyauchi A, Hruska KA. Regulation of cytosolic calcium
by parathyroid hormone and oscillations of cytosolic calcium in fibroblasts
from normal and pseudohypoparathyroid patients. Endocrinology.
1991;128(6):2825-36. doi:10.1210/endo-128-6-2825 PMID:1645251
107. Obialo CI, Clayman RV, Matts JP, Fitch LL, Buchwald H, Gillis M, Hruska
KA. Pathogenesis of nephrolithiasis post-partial ileal bypass surgery: casecontrol
study. The POSCH Group. Kidney Int. 1991;39(6):1249-
54. PMID:1895677
108. Tanaka H, Hruska KA, Seino Y, Malone JD, Nishii Y, Teitelbaum SL.
Disassociation of the macrophage-maturational effects of vitamin D from
respiratory burst priming. J Biol Chem. 1991;266(17):10888-
92. PMID:1645714
109. Gupta A, Bastani B, Purcell H, Hruska KA. Identification and localization of
pertussis toxin-sensitive GTP-binding proteins in bovine kidney glomeruli. J
Am Soc Nephrol. 1991;2(2):172-8. PMID:1954330
110. Allon M, Hruska KA. Renal adaptation to dietary phosphate restriction in rats.
Interactions with insulin and calcitriol. Diabetes. 1991;40(9):1134-
40. PMID:1936621
111. Miyauchi A, Alvarez J, Greenfield EM, Teti A, Grano M, Colucci S,
Zambonin-Zallone A, Ross FP, Teitelbaum SL, Cheresh D. Recognition of
osteopontin and related peptides by an alpha v beta 3 integrin stimulates
immediate cell signals in osteoclasts. J Biol Chem. 1991;266(30):20369-
74. PMID:1939092
112. Gupta A, Bastani B, Chardin P, Hruska KA. Localization of ral, a small Mr
GTP-binding protein, to collecting duct cells in bovine and rat kidney. Am J
Physiol. 1991;261(6 Pt 2):F1063-70. PMID:1750519
113. Civitelli R, Fujimori A, Bernier SM, Warlow PM, Goltzman D, Hruska KA,
Avioli LV. Heterogeneous intracellular free calcium responses to parathyroid
hormone correlate with morphology and receptor distribution in osteogenic
sarcoma cells. Endocrinology. 1992;130(4):2392-
400. doi:10.1210/endo.130.4.1312456 PMID:1312456
114. Hardy RW, Ladenson JH, Hruska KA, Jiwa AH, McDonald JM. The effects of
extracellular calcium and epinephrine on cytosolic-free calcium in single rat
adipocytes. Endocrinology. 1992;130(6):3694-
702. doi:10.1210/endo.130.6.1597165 PMID:1597165
115. Moskowitz DW, Hruska KA. Ca2+ uptake by endoplasmic reticulum of renal
cortex. II. Effects of uninephrectomy and parathyroidectomy. Calcif Tissue
Int. 1992;51(1):42-7. PMID:1393776
116. Moskowitz DW, Hruska KA. Ca2+ uptake by endoplasmic reticulum of renal
cortex. I. Ionic requirements and regulation in vitro. Calcif Tissue Int.
1992;51(1):35-41. PMID:1327465
117. Duncan RL, Hruska KA, Misler S. Parathyroid hormone activation of stretchactivated
cation channels in osteosarcoma cells (UMR-106.01). FEBS Lett.
1992;307(2):219-23. PMID:1379539
118. Medhora MM, Teitelbaum S, Chappel J, Alvarez J, Mimura H, Ross FP,
Hruska K. 1 alpha,25-dihydroxyvitamin D3 up-regulates expression of the
osteoclast integrin alpha v beta 3. J Biol Chem. 1993;268(2):1456-
61. PMID:7678259
119. Fujimori A, Miyauchi A, Hruska KA, Martin KJ, Avioli LV, Civitelli R.
Desensitization of calcium messenger system in parathyroid hormonestimulated
opossum kidney cells. Am J Physiol. 1993;264(6 Pt 1):E918-
24. PMID:8392807
120. Yamakawa K, Duncan R, Hruska KA. An Arg-Gly-Asp peptide stimulates
Ca2+ efflux from osteoclast precursors through a novel mechanism. Am J
Physiol. 1994;266(4 Pt 2):F651-7. PMID:8184899
121. Gupta A, Hruska KA, Martin KJ. Neurotensin binding to human embryonic
lung fibroblasts. J Recept Res. 1994;14(5):307-17. PMID:7815388
122. Gupta A, Hruska KA, Tuan TL. Angiotensin II binding to human embryonic
lung fibroblasts causes transient changes in cytosolic calcium and promotes
fibrin gel contraction. Indian J Exp Biol. 1994;32(9):603-6. PMID:7814036
123. Duncan RL, Hruska KA. Chronic, intermittent loading alters
mechanosensitive channel characteristics in osteoblast-like cells. Am J
Physiol. 1994;267(6 Pt 2):F909-16. PMID:7528987
124. Hruska KA, Chellaiah M, Rolnick F, Yamakawa K, Gupta A. Recent progress
in signal transduction related to bone remodeling and aging. Calcif Tissue Int.
1995;56 Suppl 1:S35-8. doi:10.1007/BF03354651 PMID:25773034
125. Hruska KA, Chellaiah M, Rolnick F, Yamakawa K, Gupta A. Recent progress
in signal transduction related to bone remodeling and aging. Calcif Tissue Int.
1995;56 Suppl 1:S35-8. doi:10.1007/BF03354651 PMID:25773034
126. Harter LV, Hruska KA, Duncan RL. Human osteoblast-like cells respond to
mechanical strain with increased bone matrix protein production independent
of hormonal regulation. Endocrinology. 1995;136(2):528-
35. doi:10.1210/endo.136.2.7530647 PMID:7530647
127. Hruska KA, Rifas L, Cheng SL, Gupta A, Halstead L, Avioli L. X-linked
hypophosphatemic rickets and the murine Hyp homologue. Am J Physiol.
1995;268(3 Pt 2):F357-62. PMID:7900834
128. Hruska KA, Rolnick F, Huskey M, Alvarez U, Cheresh D. Engagement of the
osteoclast integrin alpha v beta 3 by osteopontin stimulates
phosphatidylinositol 3-hydroxyl kinase activity. Ann N Y Acad Sci.
1995;760:151-65. PMID:7540372
129. Rifas L, Gupta A, Hruska KA, Avioli LV. Altered osteoblast gluconeogenesis
in X-linked hypophosphatemic mice is associated with a depressed
intracellular pH. Calcif Tissue Int. 1995;57(1):60-3. PMID:7671167
130. Hruska KA, Teitelbaum SL. Renal osteodystrophy. N Engl J Med.
1995;333(3):166-74. doi:10.1056/NEJM199507203330307 PMID:7791820
131. Gupta A, Edwards JC, Hruska KA. Cellular distribution and regulation of
NHE-1 isoform of the NA-H exchanger in the avian osteoclast. Bone.
1996;18(2):87-95. PMID:8833201
132. Duncan RL, Kizer N, Barry EL, Friedman PA, Hruska KA. Antisense
oligodeoxynucleotide inhibition of a swelling-activated cation channel in
osteoblast-like osteosarcoma cells. Proc Natl Acad Sci U S A.
1996;93(5):1864-9. PMCID:PMC39873 PMID:8700850
133. Gupta A, Miyauchi A, Fujimori A, Hruska KA. Phosphate transport in
osteoclasts: a functional and immunochemical characterization. Kidney Int.
1996;49(4):968-74. PMID:8691746
134. Chellaiah M, Hruska K. Osteopontin stimulates gelsolin-associated
phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl
kinase. Mol Biol Cell. 1996;7(5):743-53. PMCID:PMC275927 PMID:8744948
135. Chellaiah M, Fitzgerald C, Filardo EJ, Cheresh DA, Hruska KA. Osteopontin
activation of c-src in human melanoma cells requires the cytoplasmic domain
of the integrin alpha v-subunit. Endocrinology. 1996;137(6):2432-
40. doi:10.1210/endo.137.6.8641196 PMID:8641196
136. Kim YS, MacDonald PN, Dedhar S, Hruska KA. Association of 1 alpha,25-
dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane
acceptance sites. Endocrinology. 1996;137(9):3649-
58. doi:10.1210/endo.137.9.8756529 PMID:8756529
137. Kizer N, Guo XL, Hruska K. Reconstitution of stretch-activated cation
channels by expression of the alpha-subunit of the epithelial sodium channel
cloned from osteoblasts. Proc Natl Acad Sci U S A. 1997;94(3):1013-
8. PMCID:PMC19631 PMID:9023374
138. Hruska KA. Renal osteodystrophy. Baillieres Clin Endocrinol Metab.
1997;11(1):165-94. PMID:9222491
139. Rogers SA, Padanilam BJ, Hruska KA, Giachelli CM, Hammerman MR.
Metanephric osteopontin regulates nephrogenesis in vitro. Am J Physiol.
1997;272(4 Pt 2):F469-76. PMID:9140047
140. Onishi T, Hruska K. Expression of p27Kip1 in osteoblast-like cells during
differentiation with parathyroid hormone. Endocrinology. 1997;138(5):1995-
2004. doi:10.1210/endo.138.5.5146 PMID:9112398
141. Endsley JK, Phillips JA 3rd, Hruska KA, Denneberg T, Carlson J, George AL
Jr. Genomic organization of a human cystine transporter gene (SLC3A1) and
identification of novel mutations causing cystinuria. Kidney Int.
1997;51(6):1893-9. PMID:9186880
142. Gupta A, Guo XL, Alvarez UM, Hruska KA. Regulation of sodium-dependent
phosphate transport in osteoclasts. J Clin Invest. 1997;100(3):538-
49. doi:10.1172/JCI119563 PMCID:PMC508220 PMID:9239400
143. Rifas L, Cheng S, Halstead LR, Gupta A, Hruska KA, Avioli LV. Skeletal
casein kinase activity defect in the HYP mouse. Calcif Tissue Int.
1997;61(3):256-9. PMID:9262518
144. Onishi T, Zhang W, Cao X, Hruska K. The mitogenic effect of parathyroid
hormone is associated with E2F-dependent activation of cyclin-dependent
kinase 1 (cdc2) in osteoblast precursors. J Bone Miner Res.
1997;12(10):1596-605. doi:10.1359/jbmr.1997.12.10.1596 PMID:9333120
145. Teti A, Taranta A, Migliaccio S, Degiorgi A, Santandrea E, Villanova I,
Faraggiana T, Chellaiah M, Hruska KA. Colony stimulating factor-1-induced
osteoclast spreading depends on substrate and requires the vitronectin
receptor and the c-src proto-oncogene. J Bone Miner Res. 1998;13(1):50-
8. doi:10.1359/jbmr.1998.13.1.50 PMID:9443790
146. Chellaiah M, Fitzgerald C, Alvarez U, Hruska K. c-Src is required for
stimulation of gelsolin-associated phosphatidylinositol 3-kinase. J Biol Chem.
1998;273(19):11908-16. PMID:9565618
147. Stickle D, Cole B, Hock K, Hruska KA, Scott MG. Correlation of plasma
concentrations of cystatin C and creatinine to inulin clearance in a pediatric
population. Clin Chem. 1998;44(6 Pt 1):1334-8. PMID:9625061
148. Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine
nephrolithiasis. Am J Kidney Dis. 1998;32(1):153-9. PMID:9669437
149. Chellaiah MA, Hruska KA. Osteopontin. Drug News Perspect.
1998;11(6):350-5. PMID:15616623
150. Hruska KA. New insights related to aging and renal osteodystrophy. Geriatr
Nephrol Urol. 1999;9(1):49-56. PMID:10435227
151. Kizer N, Harter L, Hruska K, Alvarez U, Duncan R. Volume regulatory
decrease in UMR-106.01 cells is mediated by specific alpha1 subunits of Ltype
calcium channels. Cell Biochem Biophys. 1999;31(1):65-
79. doi:10.1007/BF02738155 PMID:10505668
152. Chellaiah M, Kizer N, Silva M, Alvarez U, Kwiatkowski D, Hruska KA.
Gelsolin deficiency blocks podosome assembly and produces increased
bone mass and strength. J Cell Biol. 2000;148(4):665-
78. PMCID:PMC2169374 PMID:10684249
153. Cheng SL, Lai CF, Fausto A, Chellaiah M, Feng X, McHugh KP, Teitelbaum
SL, Civitelli R, Hruska KA, Ross FP, Avioli LV. Regulation of alphaVbeta3
and alphaVbeta5 integrins by dexamethasone in normal human osteoblastic
cells. J Cell Biochem. 2000;77(2):265-76. PMID:10723092
154. Chellaiah MA, Soga N, Swanson S, McAllister S, Alvarez U, Wang D, Dowdy
SF, Hruska KA. Rho-A is critical for osteoclast podosome organization,
motility, and bone resorption. J Biol Chem. 2000;275(16):11993-
2002. PMID:10766830
155. Adkisson HD, Strauss-Schoenberger J, Gillis M, Wilkins R, Jackson M,
Hruska KA. Rapid quantitative bioassay of osteoinduction. J Orthop Res.
2000;18(3):503-11. doi:10.1002/jor.1100180326 PMID:10937641
156. Connolly JO, Soga N, Guo XL, Alvarez U, Hruska KA. Rac is essential in the
transformation of endothelial cells by polyoma middle T. Cell Adhes
Commun. 2000;7(5):409-22. PMID:10830619
157. Hruska KA. Pathophysiology of renal osteodystrophy Pediatr Nephrol.
2000;14:636-640.
158. Schwarze SR, Hruska KA, Dowdy SF. Protein transduction: unrestricted
delivery into all cells? Trends Cell Biol. 2000;10(7):290-5. PMID:10856932
159. Hruska KA, Guo G, Wozniak M, Martin D, Miller S, Liapis H, Loveday K,
Klahr S, Sampath TK, Morrissey J. Osteogenic protein-1 prevents renal
fibrogenesis associated with ureteral obstruction. Am J Physiol Renal
Physiol. 2000;279(1):F130-43. PMID:10894795
160. Civitelli R, Hruska K, Ralston S. Dawning of a New Era at CTI Calcif Tissue
Int. 2000;67(1):1. PMID:10908404
161. Wozniak M, Fausto A, Carron CP, Meyer DM, Hruska KA. Mechanically
strained cells of the osteoblast lineage organize their extracellular matrix
through unique sites of alphavbeta3-integrin expression. J Bone Miner Res.
2000;15(9):1731-45. doi:10.1359/jbmr.2000.15.9.1731 PMID:10976993
162. Soga N, Connolly JO, Chellaiah M, Kawamura J, Hruska KA. Rac regulates
vascular endothelial growth factor stimulated motility. Cell Commun Adhes.
2001;8(1):1-13. PMID:11775025
163. Chaudhary LR, Hruska KA. The cell survival signal Akt is differentially
activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells. J Cell
Biochem. 2001;81(2):304-11. PMID:11241670
164. Ihara H, Denhardt DT, Furuya K, Yamashita T, Muguruma Y, Tsuji K, Hruska
KA, Higashio K, Enomoto S, Nifuji A, Rittling SR, Noda M. Parathyroid
hormone-induced bone resorption does not occur in the absence of
osteopontin. J Biol Chem. 2001;276(16):13065-
71. doi:10.1074/jbc.M010938200 PMID:11278791
165. Bennett BD, Alvarez U, Hruska KA. Receptor-operated osteoclast calcium
sensing. Endocrinology. 2001;142(5):1968-
74. doi:10.1210/endo.142.5.8125 PMID:11316762
166. Vocero-Akbari, A., Chellaiah, M.A., Hruska, K.A., Dowdy, S.F. Protein
transduction: delivery of Tat-GTPase fusion proteins into mammalian cells
Methods Enzymol. 2001;332:36-49.
167. Davies MR, Hruska KA. Pathophysiological mechanisms of vascular
calcification in end-stage renal disease. Kidney Int. 2001;60(2):472-
9. doi:10.1046/j.1523-1755.2001.060002472.x PMID:11473629
168. Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy SF,
Kawamura J, Hruska KA. Rho family GTPases regulate VEGF-stimulated
endothelial cell motility. Exp Cell Res. 2001;269(1):73-
87. doi:10.1006/excr.2001.5295 PMID:11525641
169. Adkisson HD, Gillis MP, Davis EC, Maloney W, Hruska KA. In vitro
generation of scaffold independent neocartilage. Clin Orthop Relat Res.
2001;(391 Suppl):S280-94. PMID:11603712
170. Gupta A, Tenenhouse HS, Hoag HM, Wang D, Khadeer MA, Namba N, Feng
X, Hruska KA. Identification of the type II Na(+)-Pi cotransporter (Npt2) in the
osteoclast and the skeletal phenotype of Npt2-/- mice. Bone. 2001;29(5):467-
76. PMID:11704500
171. Chellaiah MA, Biswas RS, Yuen D, Alvarez UM, Hruska KA.
Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology
2-containing signaling proteins with gelsolin. J Biol Chem.
2001;276(50):47434-44. doi:10.1074/jbc.M107494200 PMID:11577104
172. Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S. Bone
morphogenetic protein-7 improves renal fibrosis and accelerates the return of
renal function. J Am Soc Nephrol. 2002;13 Suppl 1:S14-21. PMID:11792757
173. Lund RJ, Davies MR, Hruska KA. Bone morphogenetic protein-7: an antifibrotic
morphogenetic protein with therapeutic importance in renal disease.
Curr Opin Nephrol Hypertens. 2002;11(1):31-6. PMID:11753084
174. González EA, Lund RJ, Martin KJ, McCartney JE, Tondravi MM, Sampath
TK, Hruska KA. Treatment of a murine model of high-turnover renal
osteodystrophy by exogenous BMP-7. Kidney Int. 2002;61(4):1322-
31. doi:10.1046/j.1523-1755.2002.00258.x PMID:11918739
175. Hruska KA. Treatment of chronic tubulointerstitial disease: a new concept.
Kidney Int. 2002;61(5):1911-22. doi:10.1046/j.1523-
1755.2002.00331.x PMID:11967050
176. Klahr S, Morrissey J, Hruska K, Wang S, Chen Q. New approaches to delay
the progression of chronic renal failure. Kidney Int Suppl. 2002;(80):23-
6. doi:10.1046/j.1523-1755.61.s80.16.x PMID:11982808
177. Jendrisak MD, Hruska K, Wagner J, Chandler D, Kappel D. Cadaveric-donor
organ recovery at a hospital-independent facility. Transplantation.
2002;74(7):978-82. PMID:12394841
178. Chellaiah MA, Kizer N, Biswas R, Alvarez U, Strauss-Schoenberger J, Rifas
L, Rittling SR, Denhardt DT, Hruska KA. Osteopontin deficiency produces
osteoclast dysfunction due to reduced CD44 surface expression. Mol Biol
Cell. 2003;14(1):173-89. doi:10.1091/mbc.E02-06-
0354 PMCID:PMC140236 PMID:12529435
179. Uchida K, Chaudhary LR, Sugimura Y, Adkisson HD, Hruska KA. Proprotein
convertases regulate activity of prostate epithelial cell differentiation markers
and are modulated in human prostate cancer cells. J Cell Biochem.
2003;88(2):394-9. doi:10.1002/jcb.10327 PMID:12520542
180. Sugatani T, Alvarez U, Hruska KA. PTEN regulates RANKL- and
osteopontin-stimulated signal transduction during osteoclast differentiation
and cell motility. J Biol Chem. 2003;278(7):5001-
8. doi:10.1074/jbc.M209299200 PMID:12460992
181. Chellaiah MA, Hruska KA. The integrin alpha(v)beta(3) and CD44 regulate
the actions of osteopontin on osteoclast motility. Calcif Tissue Int.
2003;72(3):197-205. doi:10.1007/s00223-002-1025-6 PMID:12469249
182. Gupta A, Lee BS, Khadeer MA, Tang Z, Chellaiah M, Abu-Amer Y,
Goldknopf J, Hruska KA. Leupaxin is a critical adaptor protein in the
adhesion zone of the osteoclast. J Bone Miner Res. 2003;18(4):669-
85. doi:10.1359/jbmr.2003.18.4.669 PMID:12674328
183. Saab G, Mathew S, Chaudhary LR, Hruska KA. Post-transplant
osteodystrophy in the era of the K/DOQI guidelines. Dialysis &
Transplantation. 2003;32:651-658.
184. Rojas E, Carlini RG, Clesca P, Arminio A, Suniaga O, De Elguezabal K,
Weisinger JR, Hruska KA, Bellorin-Font E. The pathogenesis of
osteodystrophy after renal transplantation as detected by early alterations in
bone remodeling. Kidney Int. 2003;63(5):1915-23. doi:10.1046/j.1523-
1755.2003.00938.x PMID:12675872
185. Chaudhary LR, Hruska KA. Inhibition of cell survival signal protein kinase
B/Akt by curcumin in human prostate cancer cells. J Cell Biochem.
2003;89(1):1-5. doi:10.1002/jcb.10495 PMID:12682902
186. Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J, Liapis
H, Klahr S, Hruska KA. Bone morphogenic protein-7 (BMP-7), a novel
therapy for diabetic nephropathy. Kidney Int. 2003;63(6):2037-
49. doi:10.1046/j.1523-1755.2003.00035.x PMID:12753291
187. Krishnamurthy MS, Hruska KA, Chandhoke PS. The urinary response to an
oral oxalate load in recurrent calcium stone formers. J Urol.
2003;169(6):2030-
3. doi:10.1097/01.ju.0000062527.37579.49 PMID:12771711
188. Davies MR, Lund RJ, Hruska KA. BMP-7 is an efficacious treatment of
vascular calcification in a murine model of atherosclerosis and chronic renal
failure. J Am Soc Nephrol. 2003;14(6):1559-67. PMID:12761256
189. Chellaiah MA, Biswas RS, Rittling SR, Denhardt DT, Hruska KA. Rhodependent
Rho kinase activation increases CD44 surface expression and
bone resorption in osteoclasts. J Biol Chem. 2003;278(31):29086-
97. doi:10.1074/jbc.M211074200 PMID:12730217
190. Sugatani T, Alvarez UM, Hruska KA. Activin A stimulates IkappaBalpha/
NFkappaB and RANK expression for osteoclast differentiation, but not
AKT survival pathway in osteoclast precursors. J Cell Biochem.
2003;90(1):59-67. doi:10.1002/jcb.10613 PMID:12938156
191. Walling HW, Raggatt LJ, Irvine DW, Barmina OY, Toledano JE, Goldring MB,
Hruska KA, Adkisson HD, Burdge RE, Gatt CJ Jr, Harwood DA, Partridge
NC. Impairment of the collagenase-3 endocytotic receptor system in cells
from patients with osteoarthritis. Osteoarthritis Cartilage. 2003;11(12):854-
63. PMID:14629961
192. Nochi H, Sung JH, Lou J, Adkisson HD, Maloney WJ, Hruska KA.
Adenovirus mediated BMP-13 gene transfer induces chondrogenic
differentiation of murine mesenchymal progenitor cells. J Bone Miner Res.
2004;19(1):111-22. doi:10.1359/jbmr.2004.19.1.111 PMID:14753743
193. Hruska KA, Saab G, Chaudhary LR, Quinn CO, Lund RJ, Surendran K.
Kidney-bone, bone-kidney, and cell-cell communications in renal
osteodystrophy. Semin Nephrol. 2004;24(1):25-38. PMID:14730507
194. Lund RJ, Davies MR, Brown AJ, Hruska KA. Successful treatment of an
adynamic bone disorder with bone morphogenetic protein-7 in a renal
ablation model. J Am Soc Nephrol. 2004;15(2):359-69. PMID:14747382
195. Goodman WG, London G, Amann K, Block GA, Giachelli C, Hruska KA,
Ketteler M, Levin A, Massy Z, McCarron DA, Raggi P, Shanahan CM,
Yorioka N, Vascular Calcification Work Group. Vascular calcification in
chronic kidney disease. Am J Kidney Dis. 2004;43(3):572-9. PMID:14981617
196. Chaudhary LR, Hofmeister AM, Hruska KA. Differential growth factor control
of bone formation through osteoprogenitor differentiation. Bone.
2004;34(3):402-11. doi:10.1016/j.bone.2003.11.014 PMID:15003788
197. Biswas RS, Baker D, Hruska KA, Chellaiah MA. Polyphosphoinositidesdependent
regulation of the osteoclast actin cytoskeleton and bone
resorption. BMC Cell Biol. 2004;5:19. doi:10.1186/1471-2121-5-
19 PMCID:PMC441372 PMID:15142256
198. Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA. Bone
morphogenetic protein 7: a novel treatment for chronic renal and bone
disease. Curr Opin Nephrol Hypertens. 2004;13(4):417-22. PMID:15199292
199. Lu Y, Adkisson HD, Bogdanske J, Kalscheur V, Maloney W, Cheung R,
Grodzinsky AJ, Hruska KA, Markel MD. In vivo transplantation of neonatal
ovine neocartilage allografts: determining the effectiveness of tissue
transglutaminase. J Knee Surg. 2005;18(1):31-42. PMID:15742595
200. Sugatani T, Hruska KA. Akt1/Akt2 and mammalian target of rapamycin/Bim
play critical roles in osteoclast differentiation and survival, respectively,
whereas Akt is dispensable for cell survival in isolated osteoclast precursors.
J Biol Chem. 2005;280(5):3583-
9. doi:10.1074/jbc.M410480200 PMID:15545269
201. Davies MR, Lund RJ, Mathew S, Hruska KA. Low turnover osteodystrophy
and vascular calcification are amenable to skeletal anabolism in an animal
model of chronic kidney disease and the metabolic syndrome. J Am Soc
Nephrol. 2005;16(4):917-28. doi:10.1681/ASN.2004100835 PMID:15743994
202. Jendrisak MD, Hruska K, Wagner J, Chandler D, Kappel D. Hospitalindependent
organ recovery from deceased donors: a two-year experience.
Am J Transplant. 2005;5(5):1105-10. doi:10.1111/j.1600-
6143.2005.00804.x PMID:15816893
203. Hruska KA, Mathew S, Saab G. Bone morphogenetic proteins in vascular
calcification. Circ Res. 2005;97(2):105-
14. doi:10.1161/01.RES.00000175571.53833.6c PMID:16037577
204. Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is
activated after unilateral ureteral obstruction, and recombinant secreted
frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc
Nephrol. 2005;16(8):2373-
84. doi:10.1681/ASN.2004110949 PMID:15944336
205. Hruska KA, Mathew S, Davies MR, Lund RJ. Connections between vascular
calcification and progression of chronic kidney disease: therapeutic
alternatives. Kidney Int Suppl. 2005;(99):S142-51. doi:10.1111/j.1523-
1755.2005.09926.x PMID:16336568
206. Hendy GN, Hruska KA, Mathew S, Goltzman D. New insights into mineral
and skeletal regulation by active forms of vitamin D. Kidney Int.
2006;69(2):218-23. doi:10.1038/sj.ki.5000091 PMID:16408109
207. Lund RJ, Davies MR, Mathew S, Hruska KA. New discoveries in the
pathogenesis of renal osteodystrophy. J Bone Miner Metab. 2006;24(2):169-
71. doi:10.1007/s00774-005-0666-8 PMID:16502127
208. Mathew S, Davies M, Lund R, Saab G, Hruska KA. Function and effect of
bone morphogenetic protein-7 in kidney bone and the bone-vascular links in
chronic kidney disease. Eur J Clin Invest. 2006;36 Suppl 2:43-
50. doi:10.1111/j.1365-2362.2006.01663.x PMID:16884397
209. Mathew S, Lund RJ, Strebeck F, Tustison KS, Geurs T, Hruska KA. Reversal
of the adynamic bone disorder and decreased vascular calcification in
chronic kidney disease by sevelamer carbonate therapy. J Am Soc Nephrol.
2007;18(1):122-30. doi:10.1681/ASN.2006050490 PMID:17182886
210. Sugatani T, Hruska KA. MicroRNA-223 is a key factor in osteoclast
differentiation. J Cell Biochem. 2007;101(4):996-
9. doi:10.1002/jcb.21335 PMID:17471500
211. Hruska KA, Saab G, Mathew S, Lund R. Renal osteodystrophy, phosphate
homeostasis, and vascular calcification. Semin Dial. 2007;20(4):309-
15. PMID:17635820
212. De Petris L, Hruska KA, Chiechio S, Liapis H. Bone morphogenetic protein-7
delays podocyte injury due to high glucose. Nephrol Dial Transplant.
2007;22(12):3442-50. doi:10.1093/ndt/gfm503 PMID:17686813
213. Hruska KA, Mathew S, Lund R. Osteoporosis and cardiovascular disease:
lessons from chronic kidney disease. Clin Cases Miner Bone Metab.
2008;5(1):35-9. PMCID:PMC2781186 PMID:22460843
214. Mathew S, Tustison KS, Sugatani T, Chaudhary LR, Rifas L, Hruska KA. The
mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc
Nephrol. 2008;19(6):1092-
105. doi:10.1681/ASN.2007070760 PMCID:PMC2396927 PMID:18417722
215. Hruska KA, Mathew S, Lund R, Qiu P, Pratt R. Hyperphosphatemia of
chronic kidney disease. Kidney Int. 2008;74(2):148-
57. doi:10.1038/ki.2008.130 PMCID:PMC2735026 PMID:18449174
216. Mathew S, Lund RJ, Chaudhary LR, Geurs T, Hruska KA. Vitamin D receptor
activators can protect against vascular calcification. J Am Soc Nephrol.
2008;19(8):1509-
19. doi:10.1681/ASN.2007080902 PMCID:PMC2488263 PMID:18448587
217. Sugatani T, Hruska KA. Impaired micro-RNA pathways diminish osteoclast
differentiation and function. J Biol Chem. 2009;284(7):4667-
78. doi:10.1074/jbc.M805777200 PMCID:PMC2640963 PMID:19059913
218. Hruska KA, Mathew S, Lund RJ, Memon I, Saab G. The pathogenesis of
vascular calcification in the chronic kidney disease mineral bone disorder: the
links between bone and the vasculature. Semin Nephrol. 2009;29(2):156-
65. doi:10.1016/j.semnephrol.2009.01.008 PMCID:PMC2758096 PMID:1937
1806
219. Hruska KA. Vascular smooth muscle cells in the pathogenesis of vascular
calcification. Circ Res. 2009;104(6):710-
1. doi:10.1161/CIRCRESAHA.109.195487 PMID:19325156
220. Kokubo T, Ishikawa N, Uchida H, Chasnoff SE, Xie X, Mathew S, Hruska KA,
Choi ET. CKD accelerates development of neointimal hyperplasia in
arteriovenous fistulas. J Am Soc Nephrol. 2009;20(6):1236-
45. doi:10.1681/ASN.2007121312 PMCID:PMC2689906 PMID:19423694
221. Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock
ME, Lenchik L, Hruska KA, Register TC, Carr JJ. Bone morphogenetic
protein 7 (BMP7) gene polymorphisms are associated with inverse
relationships between vascular calcification and BMD: the Diabetes Heart
Study. J Bone Miner Res. 2009;24(10):1719-
27. doi:10.1359/jbmr.090501 PMCID:PMC2743282 PMID:19453255
222. Teti A, Grano M, Colucci S, Argentino L, Barattolo R, Miyauchi A, Teitelbaum
SL, Hruska KA, Zambonin-Zallone A. Voltage dependent calcium channel
expression in isolated osteoclasts Boll Soc Ital Biol Sper. 2009;65(12):1115-
1118.
223. Hruska KA, Choi ET, Memon I, Davis TK, Mathew S. Cardiovascular risk in
chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD).
Pediatr Nephrol. 2010;25(4):769-78. doi:10.1007/s00467-009-1337-
0 PMCID:PMC3719392 PMID:19898875
224. London G, Coyne D, Hruska K, Malluche HH, Martin KJ. The new kidney
disease: improving global outcomes (KDIGO) guidelines - expert clinical
focus on bone and vascular calcification. Clin Nephrol. 2010;74(6):423-
32. PMCID:PMC3770279 PMID:21084045
225. Hruska KA, Mathew S. The roles of the skeleton and phosphorus in the CKD
mineral bone disorder. Adv Chronic Kidney Dis. 2011;18(2):98-
104. doi:10.1053/j.ackd.2011.01.001 PMCID:PMC3103992 PMID:21406294
226. Sugatani T, Vacher J, Hruska KA. A microRNA expression signature of
osteoclastogenesis. Blood. 2011;117(13):3648-57. doi:10.1182/blood-2010-
10-311415 PMCID:PMC3072882 PMID:21273303
227. Manson SR, Niederhoff RA, Hruska KA, Austin PF. The BMP-7-Smad1/5/8
pathway promotes kidney repair after obstruction induced renal injury. J Urol.
2011;185(6 Suppl):2523-
30. doi:10.1016/j.juro.2011.01.034 PMCID:PMC3418146 PMID:21527199
228. Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr
JJ, Hightower RC, Xu J, Hruska KA, Freedman BI. Relationships between
calcified atherosclerotic plaque and bone mineral density in African
Americans with type 2 diabetes. J Bone Miner Res. 2011;26(7):1554-
60. doi:10.1002/jbmr.389 PMID:21437982
229. Siedlecki AM, Jin X, Thomas W, Hruska KA, Muslin AJ. RGS4, a GTPase
activator, improves renal function in ischemia-reperfusion injury. Kidney Int.
2011;80(3):263-
71. doi:10.1038/ki.2011.63 PMCID:PMC3221244 PMID:21412219
230. Manson SR, Niederhoff RA, Hruska KA, Austin PF. Endogenous BMP-7 is a
critical molecular determinant of the reversibility of obstruction-induced renal
injuries. Am J Physiol Renal Physiol. 2011;301(6):F1293-
302. doi:10.1152/ajprenal.00071.2011 PMCID:PMC3774217 PMID:2188083
6
231. Chatterjee R, Ramos E, Hoffman M, VanWinkle J, Martin DR, Davis TK,
Hoshi M, Hmiel SP, Beck A, Hruska K, Coplen D, Liapis H, Mitra R, Druley T,
Austin P, Jain S. Traditional and targeted exome sequencing reveals
common, rare and novel functional deleterious variants in RET-signaling
complex in a cohort of living US patients with urinary tract malformations.
Hum Genet. 2012;131(11):1725-38. doi:10.1007/s00439-012-1181-
3 PMCID:PMC3551468 PMID:22729463
232. Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J,
Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between
serum MCP-1 and subclinical kidney disease: African American-Diabetes
Heart Study. BMC Nephrol. 2012;13:148. doi:10.1186/1471-2369-13-
148 PMCID:PMC3534523 PMID:23151275
233. Seifert ME, de las Fuentes L, Rothstein M, Dietzen DJ, Bierhals AJ, Cheng
SC, Ross W, Windus D, Dávila-Román VG, Hruska KA. Effects of phosphate
binder therapy on vascular stiffness in early-stage chronic kidney disease.
Am J Nephrol. 2013;38(2):158-67. doi:10.1159/000353569 PMID:23941761
234. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ,
Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD,
Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate
with atherosclerotic calcified plaque in African-Americans with type 2
diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-5. doi:10.1210/jc.2012-
3038 PMCID:PMC3537092 PMID:23125289
235. Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC,
Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G,
Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel
CL, Bertoni AG, Herrington DM, Wagenknecht LE, Langefeld CD, Freedman
BI. Admixture mapping of coronary artery calcified plaque in African
Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet.
2013;6(1):97-
105. doi:10.1161/CIRCGENETICS.112.964114 PMCID:PMC3578054 PMID:
23233742
236. Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE,
Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI.
Relationships between serum adiponectin and bone density, adiposity and
calcified atherosclerotic plaque in the African American-Diabetes Heart
Study. J Clin Endocrinol Metab. 2013;98(5):1916-22. doi:10.1210/jc.2012-
4126 PMCID:PMC3644610 PMID:23543659
237. Sugatani T, Hruska KA. Down-regulation of miR-21 biogenesis by estrogen
action contributes to osteoclastic apoptosis. J Cell Biochem.
2013;114(6):1217-22. doi:10.1002/jcb.24471 PMCID:PMCID:
PMC4154486 PMID:23238785
238. Block GA, Ix JH, Ketteler M, Martin KJ, Thadhani RI, Tonelli M, Wolf M,
Jüppner H, Hruska K, Wheeler DC. Phosphate homeostasis in CKD: report
of a scientific symposium sponsored by the National Kidney Foundation. Am
J Kidney Dis. 2013;62(3):457-
73. doi:10.1053/j.ajkd.2013.03.042 PMID:23763855
239. Anyaegbu E, Davis TK, Kniska K, Hruska K, Beck A. Buyer beware! doctor
be aware!: Questions. Pediatr Nephrol. 2013;28(9):1785; answer 1787-
90. doi:10.1007/s00467-012-2338-y PMID:23111895
240. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ,
Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD,
Freedman BI. Sclerostin is positively associated with bone mineral density in
men and women and negatively associated with carotid calcified
atherosclerotic plaque in men from the African American-Diabetes Heart
Study. J Clin Endocrinol Metab. 2014;99(1):315-21. doi:10.1210/jc.2013-
3168 PMCID:PMC3879670 PMID:24178795
241. Seifert ME, de Las Fuentes L, Ginsberg C, Rothstein M, Dietzen DJ, Cheng
SC, Ross W, Windus D, Dávila-Román VG, Hruska KA. Left ventricular mass
progression despite stable blood pressure and kidney function in stage 3
chronic kidney disease. Am J Nephrol. 2014;39(5):392-
9. doi:10.1159/000362251 PMCID:PMC4066883 PMID:24818573
242. Manson SR, Song JB, Hruska KA, Austin PF. HDAC dependent
transcriptional repression of Bmp-7 potentiates TGF-β mediated renal
fibrosis in obstructive uropathy. J Urol. 2014;191(1):242-
52. doi:10.1016/j.juro.2013.06.110 PMCID:PMC4084877 PMID:23820056
243. Fang Y, Ginsberg C, Sugatani T, Monier-Faugere MC, Malluche H, Hruska
KA. Early chronic kidney disease-mineral bone disorder stimulates vascular
calcification. Kidney Int. 2014;85(1):142-
50. doi:10.1038/ki.2013.271 PMCID:PMC3836911 PMID:23884339
244. Fang Y, Ginsberg C, Seifert M, Agapova O, Sugatani T, Register TC,
Freedman BI, Monier-Faugere MC, Malluche H, Hruska KA. CKD-induced
wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and
bone disorder. J Am Soc Nephrol.
2014. doi:10.1681/ASN.2013080818 PMCID:PMCID: PMC4116062
[Available on 2015-08-01] PMID:24578135
245. Sugatani T, Hildreth BE 3rd, Toribio RE, Malluche HH, Hruska KA.
Expression of DGCR8-dependent microRNAs is indispensable for
osteoclastic development and bone-resorbing activity. J Cell Biochem.
2014;115(6):1043-7. doi:10.1002/jcb.24759 PMCID:PMCID:
PMC4079251 PMID:24420069
246. Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ,
Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA,
Register TC. Plasma FGF23 and Calcified Atherosclerotic Plaque in African
Americans with Type 2 Diabetes Mellitus. Am J Nephrol. 2015;42(6):391-
401. doi:10.1159/000443241 PMCID:PMC4732898 PMID:26693712
247. Anyaegbu EI, Shaw AS, Hruska KA, Jain S. Clinical phenotype of APOL1
nephropathy in young relatives of patients with end-stage renal disease.
Pediatr Nephrol. 2015;30(6):983-9. doi:10.1007/s00467-014-3031-
0 PMCID:PMC4406792 PMID:25530085
248. Hruska KA, Seifert M, Sugatani T. Pathophysiology of the chronic kidney
disease-mineral bone disorder. Curr Opin Nephrol Hypertens.
2015;24(4):303-
9. doi:10.1097/MNH.0000000000000132 PMCID:PMC4699443 PMID:26050
115
249. Sugatani T, Agapova O, Malluche HH, Hruska KA. SIRT6 deficiency
culminates in low-turnover osteopenia. Bone. 2015;81:168-
77. PMCID:PMC4640951 PMID:26189760
250. Seifert ME, Hruska KA. The Kidney-Vascular-Bone Axis in the Chronic
Kidney Disease-Mineral Bone Disorder. Transplantation. 2016;100(3):497-
505. PMCID:PMC4764429 PMID:26356179
251. Seifert ME, Ashoor IF, Chiang ML, Chishti AS, Dietzen DJ, Gipson DS,
Janjua HS, Selewski DT, Hruska KA. Fibroblast growth factor-23 and chronic
allograft injury in pediatric renal transplant recipients: a Midwest Pediatric
Nephrology Consortium study. Pediatr Transplant. 2016;20(3):378-
87. PMCID:PMC4818682 PMID:26880121
252. Agapova OA, Fang Y, Sugatani T, Seifert ME, Hruska KA. Ligand trap for the
activin type IIA receptor protects against vascular disease and renal fibrosis
in mice with chronic kidney disease. Kidney Int. 2016;89(6):1231-
43. PMCID:PMC4868771 PMID:27165838
253. Olson PD, Hruska KA, Hunstad DA. Androgens Enhance Male Urinary Tract
Infection Severity in a New Model. J Am Soc Nephrol. 2016;27(6):1625-
34. PMCID:PMC4884108 PMID:26449605
254. Wagenknecht LE, Divers J, Register TC, Russell GB, Bowden DW, Xu J,
Langefeld CD, Lenchik L, Hruska KA, Carr JJ, Freedman BI. Bone Mineral
Density and Progression of Subclinical Atherosclerosis in African-Americans
With Type 2 Diabetes. J Clin Endocrinol Metab. 2016;101(11):4135-
4141. PMCID:PMC5095232 PMID:27552541
255. Sugatani T, Agapova OA, Fang Y, Berman AG, Wallace JM, Malluche HH,
Faugere MC, Smith W, Sung V, Hruska KA. Ligand trap of the activin
receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic
mice with chronic kidney disease. Kidney Int. 2017;91(1):86-
95. PMCID:PMC5530394 PMID:27666759
256. Hruska KA, Sugatani T, Agapova O, Fang Y. The chronic kidney disease -
Mineral bone disorder (CKD-MBD): Advances in pathophysiology. Bone.
2017;100:80-86. PMCID:PMC5502716 PMID:28119179
257. Hruska KA, Lanske B, Moe OW. Crosstalk between kidney and bone - Bench
to bedside. Bone. 2017;100:1-3. PMID:28412470
258. Olson PD, McLellan LK, Liu A, Briden KE, Tiemann KM, Daugherty AL,
Hruska KA, Hunstad DA. Renal scar formation and kidney function following
antibiotic-treated murine pyelonephritis. Dis Model Mech. 2017;10(11):1371-
1379. PMCID:PMC5719254 PMID:28882930
259. Williams MJ, Sugatani T, Agapova OA, Fang Y, Gaut JP, Faugere MC,
Malluche HH, Hruska KA. The activin receptor is stimulated in the skeleton,
vasculature, heart, and kidney during chronic kidney disease. Kidney Int.
2018;93(1):147-158. PMID:28843411
260. Gravesen E, Lerche Mace M, Nordholm A, Hofman-Bang J, Hruska K,
Haagen Nielsen C, Kjær A, Olgaard K, Lewin E. Exogenous BMP7 in aortae
of rats with chronic uremia ameliorates expression of profibrotic genes, but
does not reverse established vascular calcification. PLoS One.
2018;13(1):e0190820. PMCID:PMC5755916 PMID:29304096
261. Olson PD, McLellan LK, Hreha TN, Liu A, Briden KE, Hruska KA, Hunstad
DA. Androgen exposure potentiates formation of intratubular communities
and renal abscesses by Escherichia coli. Kidney Int. 2018;94(3):502-
513. PMCID:PMC6109434 PMID:30041870
262. Hruska KA, Mahjoub MR. New pathogenic insights inform therapeutic target
development for renal osteodystrophy. Kidney Int. 2019;95(2):261-
263. PMID:30665565