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Randolph Elble, Ph.D.

Associate Professor

About

Contact

217.545.7381

Randolph Elble <relble2@siumed.edu>

 

Professional Experience

Southern Illinois University School of Medicine, Springfield IL 2005

 

Research Interest and Specialties

Most of my lab is dedicated to determining the role of CLCA2 in mammary epithelial differentiation, DNA damage response, and breast cancer progression. As a co-discoverer of the CLCA gene family, I identified numerous members of the CLCA family from bovine, mouse, and humans and showed that certain members of the family are stress-responsive inhibitors of cell proliferation that are downregulated with tumor progression. I corrected previously published structural predictions and showed that CLCA2 is a type I transmembrane protein whose ectodomain is cleaved and shed from the cell surface. My lab is probing the molecular and physiological functions of this protein in cultured cells and a mouse knockout model. To this end, we have identified interacting proteins that illuminate its role in differentiation and response to DNA damage in breast epithelium. These studies led to the key discovery that CLCA proteins regulate intracellular calcium signaling.

 

 

 

 

 

 

 

Education

School: 
B.A. DePauw University, Greencastle, Indiana, USA, Zoology; Ph.D. Indiana University, Bloomington, Indiana, USA, Genetics , Training: Cold Spring Harbor Laboratory , NY, USA ,Other training - Molecular Genetics of Fission Yeast; Cornell University, Ithaca, NY, USA, Postdoctoral Fellow -Yeast genetics of DNA replication control, AACR Workshop, Keystone, CO, USA, NIH training grant - Histopathology of Neoplasia

Patents

Pauli, B. U., Elble, R. C., and Gruber, A. D. 2002. Nucleotide sequences encoding mammalian calcium-activated chloride channel-adhesion molecules. U.S. patent #6309857 and 6692939.

Pauli, B. U., Elble, R. C., and Gruber, A. D. 2008. Calcium-activated chloride channel proteins and their use in antimetastatic therapy. U.S. patent #7338937.

Tabs