In the second year at SIU Medicine, the curriculum is fully integrated around organ systems. Materials integrate the disciplines of clinical medicine, immunology, microbiology, pathology, pharmacology, public health populations and radiology into four, nine week long core instructional units arranged around organ systems.

Unit 1-HII (Hematology, Immunology, & Infection)

Unit 2- CRR (Cardiovascular, Respiratory, & Renal)

Unit 3- NMB (Neuromuscular Behavior)

Unit 4-ERG (Endocrine, Reproductive, & Gastrointestinal). 

Examinations are administered at the end of each unit on a pass/fail grading scale. The second-year curriculum is nine months long with a two-week winter break. Students usually take Step 1 of the U.S. Medical Licensure Exam (USMLE) at the end of the second-year curriculum.