Eight laboratories provide state of the art research and research training in Auditory and Vestibular Anatomy, Pharmacology, Physiology of Taste and Smell, Cancer Molecular Biology and Genetics.
In alphabetical order these are headed by Carol Bauer, MD; Kathy Campbell, PhD; Don Caspary, PhD; and Leonard Rybak, MD, PhD. Special emphasis is on understanding basic mechanisms and their application to clinical problems such as ototoxicity, aging, Alzheimer's Disease, tinnitus, and cancer.
Kathleen CM Campbell, PhD is Professor and Director of Audiology Research at Southern Illinois University School of Medicine in Springfield, IL. She conducts translational research discovering, patenting, and developing pharmacologic otoprotective agents to prevent or provide rescue from noise-induced hearing loss and tinnitus, to prevent cisplatin-induced hearing loss and both central and peripheral neuropathy, radiation-induced oral mucositis, and aminoglycoside induced hearing loss and vestibular disorders. The focus of her current laboratory studies include optimizing D-methionine dosing to prevent and provide rescue from noise-induced hearing loss and tinnitus, to determine the maximum length of time that pharmacologic intervention can be effective after noise cessation, and to determine optimal D-methionine dosing in preparation for clinical trials to prevent aminoglycoside induced hearing loss and vestibular disorders. She has successfully completed clinical trials to prevent cisplatin-induced hearing loss and radiation induced oral mucositis. She is funded by the Department of Defense to conduct clinical trials using D-methionine to prevent noise-induced hearing loss. Her currently active funding from the National Institutes of Health and the US Department of Defense exceeds 6 million dollars.
- Investigate the effects of toxic compounds on auditory function, morphology and biochemistry.
- Investigate potential protective agents their and mechanisms against ototoxic compounds.
- Determine the interaction between development and ototoxicity.
- Heavy Metals
- Loop Diuretics
- Aminoglycoside Antibiotics
- Endocochlear Potential (EP)
- Whole Eighth Nerve Compound Action Potential (CAP)
- Auditory Brainstem Response (ABR)
- Intracellular Potentials of the Stria Vascularis (strial potentials)
- Light Microscopy (LM)
- Scanning Electron Microscopy (SEM)
- Transmission Electron Microscopy (TEM)
- Cochlear Adenosine Receptors
- Antioxidant Enzymes
- Cochlear Glucose Metabolism
- High Pressure Liquid Chromatography
- Pharmacokinetics of Ototoxic Compounds
Vickram Ramkumar, Ph.D., Department of Pharmacology
George Dunaway, Ph.D., Department of Pharmacology