Laurent Brard, MD, PhD
Dr. Laurent Brard is Professor of Obstetrics and Gynecology at Southern Illinois University (SIU) School of Medicine, chief of the Division of Gynecologic Oncology in the Department of Obstetrics and Gynecology, director of the basic research laboratory of the Division of Gynecologic Oncology in the Department of Obstetrics and Gynecology and full member of the Simmons Cancer Institute at SIU. Dr. Brard is a nationally and internationally recognized gynecologic oncologist. He has published extensively in this field, including in the areas of molecular and cancer biology, pre-clinical drug development and novel treatments. His clinical focus is on the treatment of women's cancers. He has conducted investigator-initiated and participated in national (through the Gynecologic Oncology Group (GOG), now NRG Oncology) clinical trials of novel therapeutics with an emphasis on recurrent ovarian cancers. His research interests span five areas: (1) Gynecologic Cancer Health Disparities, (2) Biomarker Discovery in Gynecological Cancer, (3) Cancer Drug Discovery and Development (based on natural or synthetic drugs and drug re-purposing), (4) Ovarian Cancer Genomics (potentially leading to new biomarkers and druggable targets) and (5) Novel therapeutics - clinical trials for gynecologic cancers. He has been the recipient of several NIH and foundation grants to pursue these areas of research. Dr. Brard is principal investigator at the SIU School of Medicine for the P20 CA192987 NIH/NCI grant Addressing Rural Cancer Health Disparities: An SCC-SIUSM Partnership. The goal of this grant is to build a collaborative partnership between SIU School of Medicine and the NCI-designated Siteman Cancer Center (SCC) at Washington University (WUSTL) to promote training and research in the population
Ongoing EXTERNAL Research Support
1. P20CA192987 Brard (PI) 09/08/2015 - 08/31/2018
NIH/NCI $1,306,000 (TC; $652,994 SIUSM)
1/2 Addressing Rural Cancer Health Disparities: An SCC-SIUSM Partnership
The overall goal is to establish a highly integrated research and training collaboration focused on rural cancer health disparities between Southern Illinois University School of Medicine (SIUSM), an institution that serves the population of Downstate Illinois, a largely rural and socioeconomically disadvantaged region with significant cancer health disparities, and the Siteman Cancer Center at Washington University in St. Louis (SCC-WUSTL), an NCI-designated Cancer Center. The Partnership will build SIUSM’s research capacity and success conducting NIH-funded cancer disparity research, while also enhancing SCC’s rural cancer awareness, research and reach. By doing so, the Partnership will contribute to reducing the cancer health disparities that persist in rural populations.
Role: PI (SIUSM)
2. ORNLLDRD8831 Brard (Co-PI subcontract) 10/1/2017 - 9/30/2019
DOE $830,000 (TC; $120,000 SIUSM)
A Quantitative, Systems Biology, Multi-omic Approach to Diagnose and Predict Response to Treatment for Gynecologic Cancers
The overall goal of this project is to leverage microbial ecological analysis to identify microbial signatures that can 1) detect a malignancy earlier in gynecologic cancer pathology, 2) provide preoperative staging of disease, and 3) indicate response to chemotherapy intervention
Role: Co-PI (SIUSM)
Ongoing INTERNAL Research Support
1. Team Science Grant (TSG) Brard L./Braundmeier-Fleming A. (Co-PIs) 07/01/2017 - 06/30/2019
SIU School of Medicine $100,000 (TC)
Machine Learning Approach for Early Detection and Individualized Treatment of Ovarian Cancer
The project goals are to establish if there is a microbial signature associated with ovarian cancer (OC) and if this signature could be utilized for OC screening to optimize treatment strategies and aide in the determination of treatment success (prognosis).
2. Team Science Grant (TSG) Brard L./Hales B. (Co-PIs) 07/01/2014 - 06/30/2016
SIU School of Medicine $100,000 (TC) NCE 07/01/2016 – 12/31/2017
Flaxseed as Maintenance Therapy for Ovarian Cancer Patients in Remission
The project goals are to determine the feasibility of administering a daily 20g dose of ground flaxseed to ovarian cancer patients in clinical remission and describe the PFS in ovarian cancer patients in clinical remission following adjuvant chemotherapy and flaxseed supplementation.
Past EXTERNAL Research Support
1. R03CA181907 Brard (PI) 12/01/2013 - 11/30/2015
NIH/NCI $147,500 (TC) NCE 12/01/2015 - 11/30/2016
Diagnostic Utility of Culdocentesis in Patients with a Suspicious Adnexal Mass
The project goal is to determine if tumor markers (CA125 and HE4) from cul-de-sac washings and subsequent
cytology correlate with ovarian cancer diagnosis in patients with an adnexal mass suspicious for malignancy.
2. L30 CA170963 Brard (PI) 07/01/2012 - 06/30/2014
NIH/NCI $70,000 (TC)
Treatment and Biomarker Discoveries for Ovarian Cancer
3. R01CA136491 Brard L (PI) 06/01/2009 - 06/30/2010
NCI/NIH $2,100,000 (TC) was 06/01/2009 - 04/30/2014
Development of an Assay for the Early Detection of Ovarian Cancer.
Ovarian cancer is one of the most lethal cancers affecting women. This is due to the inability to detect it while still localized to the ovaries. Early detection would result in a 90% survival rate. LPA, a currently controversial biomarker for ovarian cancer diagnosis, is the subject of this application. A simple new method for detecting LPA and a fresh approach to validating LPA’s reliability as an accurate biomarker would emanate from the proposed studies.
4. R01EB002044 Strongin R (PI) 07/31/2007 - 06/30/2010
NIBIB $720,000 (TDC)
Synthesis and Study of Novel Sensing Agents.
The major goals of this project were to contribute to (i) clarifying the current understanding of the role of homocysteine in disease and (ii) facilitate the study homocysteine in natural media.
5. P41RR001395 - Supplemental Smith P (PI) 10/01/2009 - 06/30/2010
BioCurrents Research Center - Mechanisms of Cisplatin Resistance in Ovarian Cancer
The major goals of this project were to understand the genetic and phenotypic differences between primary and metastatic ovarian cancer growths that may affect therapeutic response. We expected to genotype each tumor and match the genetic differences to drug response phenotypes including probing cisplatin sensitivity relative to the regulation of drug efflux systems.
Role: Significant Contributor
6. R21NS051408 Brard L (PI) 12/01/2007 - 11/30/2009
NIH/NINDS $335,190 (TC)
High-Risk Neuroblastoma: A Devastating Childhood Cancer.
The major goals of this project were to develop new therapeutic agents for neuroblastoma.
7. K12HD043447 Coustan DR (PI) 01/01/2006 - 07/31/2008
BIRCWH $100,000 (TDC)
3-Bromoacetoxy-Calcidiol as a Novel agent in Ovarian Cancer Therapy.
BIRCWH (Building Interdisciplinary Research Careers in Women’s Health) Scholars is a NIH funded institutional K12 mechanism that protects 75% of the time for young MD and/or PhD researchers so as to help launch their careers toward independent funding. The major goal of this BIRCWH project was to test 3-bromoacetoxy-calcidiol in ovarian cancer cell lines and an animal model.
8. Ovarian Cancer Research Fund, Inc. Brard L (PI) 01/01/2006 - 12/31/2007
Individual Investigator Grant (Awarded) $100,000 (TC)
Liposomal Iron Chelator Derivatives in Ovarian Cancer Therapy.
The major goals of this project were the synthesis, development and testing of novel liposomal iron chelators and derivatives in ovarian cancer cell lines.
9. APGO/Organon Med Ed Research Award Brard L (PI) 07/01/2003 - 06/30/2004
APGO/Organon $15,000 (TC)
End of Life and Complementing Care: Development and Integration of a Longitudinal Resident Teaching Curriculum into a Gynecologic Oncology Rotation.
The major goal of this project was to develop a resident curriculum to expand knowledge in the field of palliative care pertaining to gynecologic oncology patients.
Past INTERNAL Research Support
1. Patient-Oriented Research Grant (PORG) Brard L./Hales B. (Co-PIs) 01/01/2014-03/30/2015
SIU School of Medicine $25,000 (TC)
Assessment of Estrogen Metabolite Ratios as a Predictive Biomarker for Ovarian Cancer
The project goal was to determine if the ratio of the estrogen metabolites, 2-OHE1/16α-OHE1, in urine correlates with a diagnosis of epithelial ovarian cancer.
2. Team Science Grant (TSG) Campbell K. (PI) 07/01/2013-06/30/2015
Simmons Cancer Institute/SIU School of Medicine $100,000 (TC)
Objective Electrophysiological Analysis of "Chemobrain" through the Auditory System
The project goal was to determine if a non-invasive, time-efficient auditory electrophysiological method can detect chemobrain.
3. EAM-Award Hayashi K (PI) 04/01/2012-03/30/2013
SIU-School of Medicine $50,000 (TC)
Does Niclosamide inhibit ovarian tumor growth and progression regulated by WNT7A in a pre‐clinical model?
The major goal of this project was to determine the potential of Niclosamide to inhibit ovarian cancer in vitro and in vivo. This data will then be used to apply for NIH funding.
4. EAM-Near Miss Award Brard L (PI) 04/01/2011-09/30/2012
SIU-School of Medicine $12,500 (TC)
A Phase I Trial of Bithionol for Recurrent Epithelial Ovarian Cancer.
The major goal of this project was to perform a pilot efficacy trial of Bithionol in an animal model of ovarian cancer. This data will then be used to apply for NIH or FDA funding for a human Phase 1 trial.
5. National Center of Excellence in Women’s Health Brodsky A (PI) 11/01/2008-04/01/2010
Innovations in Women’s Health Research Seed Grant $20,000 (TC)
(Brown University / Women & Infants Hospital)
Exploring cisplatin sensitivity of primary and metastatic ovarian tumors
The aim of this seed grant was to understand the genetic differences between primary and metastatic ovarian cancer growths that may affect therapeutic response using comparative genomic hybridization (CGH) and mRNA expression profiling.
6. Seed Grant Brown University Brodsky A (PI) 03/01/2007-02/28/2008
Office of the Vice President for Research $90,000 (TC)
Developing an Integrated Genomic Approach to Explore the Antitumor Activity of Vitamin D and Derivatives to Treat Ovarian Cancer.
The aim of this seed grant was to take a global genomic view to understand the effect of vitamin D (calcitriol) and the vitamin D derivative, MT19C, on ovarian tumors.
7. Seed Grant Brown University Brard L (PI) 02/01/2005-06/30/2007
Office of the VP for Research $75,000 (TC)
Development and Optimization of Novel Chemotherapeutic Agents for Cancer.
The major goals of this project were the synthesis, development and testing of novel chemotherapeutic agents based on the vitamin D lead compound developed in the laboratory.
8. Seed Grant Brard L (PI) 05/01/2003 - 04/31/2006
Department of Obstetrics and Gynecology $10,000 (TC)
Evaluation of Iron Chelators in Tandem with Vitamin D Analogs in the Treatment of Ovarian Cancer in an Animal Model.
The major goal of this project was to test a combination of two novel classes of chemotherapeutic agents in an ovarian cancer animal model.
9. Division Grant Brard L (PI) 07/01/2002 - 06/30/2003
Program in Women’s Oncology (WIHRI) $15,000 (TC)
The Use of Iron Chelators in the Treatment of Gynecologic Malignancies.
The major goals of this project were to develop iron chelators as novel chemotherapeutic agents in gynecologic malignancies.
1. Marks TJ, Yamamoto Y, Brard L, Giardello M. Method for Catalytic Polymerization of Substituted Acrylates. US Patent 5,312,881 (granted May 17, 1994).
2. Brard L, Kalkunte S, Singh R. Heterocycles and Derivatives Thereof and Methods of Manufacture and Therapeutic Use. PCT/US 2006/047320. Published June 21, 2007.
3. Brard L, Kalkunte S, Singh R, Strongin R, Alpturk O. Organometallic Compounds as Therapeutic Agents. WO/2008/070557, PCT/US2007/086080. Published June 12, 2008.
4. Brard L, Singh RK, Kim K, Sholler G. N-Amino Tetrahydrothiazine Derivatives, Method of Manufacture and Use. WO/2008/091946, PCT/US2008/051794. Published July 31, 2008.
5. Sholler G, Sundaresha HM, Kalkunte S, Singh RK, Brard L, Kim K. Nitrofuran Compounds for The Treatment of Cancer and Angiogenesis. PCT/US 2007/001527. Published September 27, 2008. Licensed to Metronom-X Inc. Underwent a phase-IIb clinical trial for treatment of high risk pediatric neuroblastoma and medulloblastoma.
6. Singh AP, Kalkunte S, Singh RK, Vorsa N, Brard L, Schaich KM, Kim K. Compositions of “FAO-Free” Cranberry extracts, their complexes and Biological applications. (2006 March): US Patent applied.