Current Research Projects

1. New Antimicrobial Agents to Eradicate Infection and Sterilize Burn Wounds

The ability to utilize antimicrobial peptides for the prevention of burn wound infections may significantly reduce infection rates and thus, mortality in high-risk patients. We are measuring the ability of antimicrobial peptides to sterilize burn wounds in an animal model. Success in this experiment may justify further experiments in a clinical setting. The long-term goal is to use these compounds as a better alternative to topical antibiotics to eradicate microorganisms in burn wounds.

2. ADSC Transplantation Potentiates Tissue Reorganization and Repair

Interest in adipose-derived mesenchymal stem cells (ADSC) in promoting tissue regeneration is currently under investigation. However, its effect on skin regeneration during tissue expansion in the setting of a radiated field has yet to be determined. We will test to see if ADSC transplantation will decrease tissue damage and enhance the efficiency of tissue expansion in animals treated with radiotherapy.

3. Heterotopic Ossification: Further Defining Cells of Origin

The goal of the project is to better understand the signaling pathways involved in heterotopic ossification formation and how stem cells contribute to this abnormal bone formation.

4. Evaluation of Hyperbaric Oxygen Treatment Effects on Peripheral Nerve Regeneration

The primary aim of this project is to improve outcomes after nerve injuries. There is evidence that hyperbaric oxygen treatment positively affects nerve recovery time. SIU is one of the few institutions that possess a small animal hyperbaric chamber. We will evaluate peripheral nerve repairs in a rodent model of nerve injury.