Physiology recent research achievements

Recent Publications

Nordman JC, Bartsch CJ, Li Z.. Opposing effects of NMDA receptor antagonists on early life stress-induced aggression in mice. Aggress Behav. 2022 May;48(3):365-373. doi: 10.1002/ab.22022. Epub 2022 Feb 4. PMID: 35122262
Bartsch CJ, Nordman JC. Promises and Pitfalls of NMDA Receptor Antagonists in Treating Violent Aggression. Front Behav Neurosci. 2022 Jun 21;16:938044. doi: 10.3389/fnbeh.2022.938044. eCollection 2022. PMID: 35801096

Nordman JC. Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression. Int J Biochem Cell Biol. 2022 Jan;142:106120. doi: 10.1016/j.biocel.2021.106120. Epub 2021 Nov 23. PMID: 34823006

Ferdousy S, Chen B.  An assessment of genome-editing efficiency of a newly developed Cas9 in C. elegans. MicroPubl Biol. 2022 Jul 17;2022:10.17912/micropub.biology.000601. doi: 10.17912/micropub.biology.000601. eCollection 2022.

McGee SR, Rajamanickam S, Adhikari S, Falayi OC, Wilson TA, Shayota BJ, Cooley Coleman JA, Skinner C, Caylor RC, Stevenson RE, D' Angioli Costa Quaio CR, Wilke BC, Bain JM, Anyane-Yeboa K, Brown K, Greally JM, Bijlsma EK, Ruivenkamp CAL, Politi K, Arbogast LA, Collard MW, Huggenvik JI, Elsea SH, Jensik PJ.  Expansion and mechanistic insights of de novo DEAF1 variants in DEAF1-associated neurodevelopmental disorders. Hum Mol Genet. 2022 Aug 18:ddac200. doi: 10.1093/hmg/ddac200. PMID: 35981081

Chilamkurthy R, White AA, Pater AA, Jensik PJ, Gagnon KT. Efficient Cloning and Sequence Validation of Repetitive and High GC-Content Short Hairpin RNAs. Hum Gene Ther. 2022 Aug;33(15-16):829-839. doi: 10.1089/hum.2021.273. PMID: 35726380

Stallings CE, Kapali J, Evans BW, McGee SR, Ellsworth BS.  FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth. Endocrinology. 2022 Feb 1;163(2):bqab263. doi: 10.1210/endocr/bqab263.PMID: 34971379

Young MJ, Sachidanandam R, Hales DB, Brard L, Robinson K, Rahman MM, Khadka P, Groesch K, Young CKJ. Identification of Somatic Mitochondrial DNA Mutations, Heteroplasmy, and Increased Levels of Catenanes in Tumor Specimens Obtained from Three Endometrial Cancer Patients. Life (Basel). 2022 Apr 9;12(4):562. doi: 10.3390/life12040562. PMID: 35455053

Ageely EA, Chilamkurthy R, Jana S, Abdullahu L, O'Reilly D, Jensik PJ, Damha MJ, Gagnon KT. Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles. Nat Commun. 2021 Nov 15;12(1):6591. doi: 10.1038/s41467-021-26989-z. PMID: 34782635

Tan H, Wu G, Wang S, Lawless J, Sinn A, Chen D, Zheng Z. Birth Defects Res. Prenatal exposure to atrazine induces cryptorchidism and hypospadias in F1 male mouse offspring. 2021 Apr 1;113(6):469-484. doi: 10.1002/bdr2.1865. Epub 2021 Jan 19. PMID: 33463082 Free PMC article.

Weston WC, Hales KH, Hales DB. Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism. Molecules. 2021 Sep 18;26(18):5674. doi: 10.3390/molecules26185674. PMID: 34577143

Pal P, Starkweather KN, Hales KH, Hales DB. A Review of Principal Studies on the Development and Treatment of Epithelial Ovarian Cancer in the Laying Hen Gallus gallus. Comp Med. 2021 Aug 1;71(4):271-284. doi: 10.30802/AALAS-CM-20-000116. Epub 2021 Jul 29. PMID: 34325771

Chang J, Wang S, Zheng Z. Etiology of Hypospadias: A Comparative Review of Genetic Factors and Developmental Processes Between Human and Animal Models. Res Rep Urol. 2020 Dec 24;12:673-686. doi: 10.2147/RRU.S276141. eCollection 2020.

Wang S, Lawless J, Zheng Z. Prenatal low-dose methyltestosterone, but not dihydrotestosterone, treatment induces penile formation in female mice and guinea pigs. Biol Reprod. 2020 May 26;102(6):1248-1260. doi: 10.1093/biolre/ioaa035. PMID: 32219310

Choi PW, Bahrampour A, Ng SK, Liu SK, Qiu W, Xie F, Kuo WP, Kwong J, Hales KH, Hales DB, Wong KK, Norwitz ER, Chow CK, Berkowitz RS, Ng SW. Characterization of miR-200 family members as blood biomarkers for human and laying hen ovarian cancer. Sci Rep. 2020 Nov 18;10(1):20071. doi: 10.1038/s41598-020-77068-0. PMID: 33208870

Pal P, Hales K, Hales DB. The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling. Oncotarget. 2020 Oct 6;11(40):3646-3659. doi: 10.18632/oncotarget.27760. eCollection 2020 Oct 6. PMID: 33088425

Choi PW, So WW, Yang J, Liu S, Tong KK, Kwan KM, Kwok JS, Tsui SKW, Ng SK, Hales KH, Hales DB, Welch WR, Crum CP, Fong WP, Berkowitz RS, Ng SW. MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread. Oncogene. 2020 May;39(20):4045-4060. doi: 10.1038/s41388-020-1264-x. Epub 2020 Mar 25. PMID: 32214198

Hiremath DS, Priviero FBM, Webb CR, KO C, Narayan P. Constitutive LH receptor activity impairs NO mediated penile smooth muscle relaxation. Reproduction. 2020 Oct1: doi:10.1530/REP-20-0447. PMID: 33112284
Wang S, Lawless J, Zheng Z. Prenatal low-dose methyltestosterone, but not dihydrotestosterone, treatment induces penile formation in female mice and guinea pigs†. Biol Reprod. 2020 May 26;102(6):1248-1260. doi: 10.1093/biolre/ioaa035. PMID: 32219310; PMCID: PMC7253790.

Hiremath DS, Geerling EC, Hai L, Narayan P. High levels of androgens cause chondrocyte accumulation and loss of smooth muscle in the mouse penile body†. Biol Reprod. 2020 May 26;102(6):1225-1233. doi: 10.1093/biolre/ioaa023. PMID: 32068232.

McGee SR, Rose GM, Jensik PJ. Impaired memory and marble burying activity in deformed epidermal autoregulatory factor 1 (Deaf1) conditional knockout mice. Behav Brain Res. 2020 Feb 17;380:112383. doi: 10.1016/j.bbr.2019.112383. Epub 2019 Nov 26. PMID: 31783086.

Griffith CM, Macklin LN, Cai Y, Sharp AA, Yan XX, Reagan LP, Strader AD, Rose GM, Patrylo PR. Impaired Glucose Tolerance and Reduced Plasma Insulin Precede Decreased AKT Phosphorylation and GLUT3 Translocation in the Hippocampus of Old 3xTg-AD Mice. J Alzheimers Dis. 2019;68(2):809-837. doi: 10.3233/JAD-180707. PMID: 30775979.

Wang S, Zheng Z. Insights Figure for "Differential cell proliferation and cell death during the urethral groove formation in guinea pig model". Pediatr Res. 2019 Oct;86(4):546. doi: 10.1038/s41390-019-0462-0. Epub 2019 Jun 18. PMID: 31212305.