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clinical trials

Clinical trials and research studies

At SIU Medicine, our researchers perform clinical trials and research studies with the aim of translating findings into new, more effective treatments.
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Activity Status

  • Active, not recruiting (3)
  • Active, recruiting (11)

Treatment

  • Depression (2)
  • Diseases of the Lungs (2)
  • Heart Disease (1)
  • High Blood Pressure (Hypertension) (4)
  • Schizophrenia (2)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • (-) Internal Medicine (9)
  • (-) Psychiatry (5)
  • Alzheimer's Center (3)
  • Cardiology (2)
  • Cardiothoracic Surgery (1)
  • Dermatology (1)
  • Infectious Diseases (1)
  • Men's health (1)
  • Neurology (10)
  • Obstetrics and Gynecology (3)
  • Pediatrics (1)
  • Pulmonary and Critical Care (3)
  • Simmons Cancer Institute (8)
  • Urology (3)
  • Vascular Surgery (2)
  • Women's health (1)
Reset

Filter Results

Activity Status

  • Active, not recruiting (3)
  • Active, recruiting (11)

Treatment

  • Depression (2)
  • Diseases of the Lungs (2)
  • Heart Disease (1)
  • High Blood Pressure (Hypertension) (4)
  • Schizophrenia (2)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • (-) Internal Medicine (9)
  • (-) Psychiatry (5)
  • Alzheimer's Center (3)
  • Cardiology (2)
  • Cardiothoracic Surgery (1)
  • Dermatology (1)
  • Infectious Diseases (1)
  • Men's health (1)
  • Neurology (10)
  • Obstetrics and Gynecology (3)
  • Pediatrics (1)
  • Pulmonary and Critical Care (3)
  • Simmons Cancer Institute (8)
  • Urology (3)
  • Vascular Surgery (2)
  • Women's health (1)
Showing: 14 Results
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Trial
Infectious Diseases

A Phase 2/3, Randomized, Double-blind, Placebo-controlled, Multicenter, Prospective Study to Assess the Efficacy, Safety, and Pharmacokinetics of Orally Administered Epetraborole in Patients with Treatment-refractory Mycobacterium aviu

Active recruiting

The purpose of this clinical trial is to assess the effectiveness of Epetraborole, taken once daily, in patient populations with treatment-refractory MAC lung disease.

Eligible patients include those who currently have a positive MAC sputum culture despite receiving a combination regimen of at least 2 antimycobacterial agents administered for at least 6 months.

Contact: Katherine Martz phone217-545-4342 emailkmartz35@siumed.edu
Trial
Psychiatry

A PRospective, Multi-cEnter, Randomized Controlled Blinded Trial DemOnstrating the Safety and Effectiveness of VNS Therapy® System as AdjunctivE Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)

Active recruiting

The primary objective of this study is to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing at least a 50% reduction in baseline depressive symptom severity, based on Montgomery Åsberg Depression Rating Scale (MADRS) total score, at 12 months from randomization.

Contact: Oladele (Dickson) Owasoyo phone217-545-7231 emailoowasoyo94@siumed.edu
Trial
Internal Medicine

AstraZeneca BaxHTN: A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypert

Active not recruiting

The purpose of this clinical trial is to trial is to learn more about a new, investigational, once daily medication, called baxdrostat, and its ability to lower blood pressure in individuals not responding to their current treatment.

Contact: Emily Starkey phone217-545-7616 emailestarkey74@siumed.edu
Trial
Psychiatry

Click: Study to Evaluate the Efficacy and Safety of a Digital Therapeutic as an Adjunct to Standard-of-Care Antipsychotic Therapy in Adult and Late Adolescent Participants with Experiential Negative Symptoms of Schizophrenia

Active recruiting

CT-155-R-001: The purpose of this study is to investigate if digital therapeutics (a moblie software application) can help treat certain symptoms of schizophrenia. 

Contact: Oladele (Dickson) Owasoyo phone217-545-7231 emailoowasoyo94@siumed.edu
Trial
Psychiatry

Click Therapeutics CT-155-R-01

Active recruiting

To evaluate the efficacy and safety of CT-155 in reducing experiential negative symptoms, compared with a Digital Control, in adult and late adolescent participants diagnosed with schizophrenia.

Contact: Oladele (Dickson) Owasoyo phone217-545-7231 emailoowasoyo94@siumed.edu
Trial
Pulmonary and Critical Care

ENCORE - A Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy and Safety of an Amikacin Liposome Inhalation Suspension (ALIS)-Based Regimen in Adult Subjects with Newly Diagnosed Nontuberculous Myco

Active recruiting

The purpose of this clinical trial is to assess the effectiveness of ARIKAYCE, inhaled once daily, in patient populations with mild and untreated MAC lung infection. 

Eligible patients include those who currently have a positive MAC sputum culture and have not received treatment for their infection.

Contact: Katherine Martz phone217-545-4342 emailkmartz35@siumed.edu
Trial
Internal Medicine

HyPhen: Hypertension Phenotype Study

Active recruiting

This is a local research study to relate heart health and various components found in your body (body fat, sodium, etc.) to high blood pressure during pregnancy, and those with apparently normal blood pressure.

Eligible participants include those with high blood pressure, those receiving treatment for their high blood pressure, women who had high blood pressure during pregnancy, and those with apparently normal blood pressure.

Contact: Kristin King phone217-545-7511 emailbpresearch@siumed.edu
Trial
Psychiatry

ImpactTD Registry: A prospective multicenter study to characterize the natural history of tardive dyskinesia (TD) and investigate the real-world effectiveness of deutetrabenazine on the multidimensional impact of TD

Active recruiting

TV50717-CNS-40223: The purpose of this study is to get a better understanding of the disease course of tardive dyskinesia and the impact it has on individuals’ lives. In subjects who may begin on deutetrabenazine (AUSTEDO®) treatment during the study, it will also help investigate the real-world effectiveness of this treatment, particularly on a person’s quality of life.

Contact: Oladele (Dickson) Owasoyo phone217-545-7231 emailoowasoyo94@siumed.edu
Trial
Internal Medicine

PE-TRACT

Active recruiting

PULMONARY EMBOLISM – THROMBUS REMOVAL WITH CATHETER-DIRECTED THERAPY

Contact: Katie Mottershaw phone217-545-7387 emailkmottershaw33@siumed.edu
Trial
Internal Medicine

Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy (PE-TRACT)

Active recruiting

The study is designed to identify the best way to treat pulmonary embolism- with blood thinners alone or blood thinners with catheter directed therapy.

Contact: Katie Mottershaw phone217-545-7387 emailkmottershaw33@siumed.edu
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