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clinical trials

Clinical trials and research studies

At SIU Medicine, our researchers perform clinical trials and research studies with the aim of translating findings into new, more effective treatments.
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Activity Status

  • Active, recruiting (5)

Treatment

  • (-) Breast Cancer (3)
  • (-) Diseases of the Lungs (2)
  • Abdominal Aortic Aneurysm (1)
  • Alzheimer's Disease (3)
  • Cervical Cancer (1)
  • Depression (2)
  • Endometrial Cancer (1)
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  • Epilepsy (5)
  • Erectile Dysfunction (ED) (1)
  • Heart Disease (1)
  • High Blood Pressure (Hypertension) (8)
  • Leukemia (1)
  • Male Infertility (1)
  • Melanoma (1)
  • Myeloma (1)
  • Neuro-Critical Care (1)
  • Ovarian Cancer (3)
  • Parkinson's Disease (1)
  • Psoriasis (1)
  • Schizophrenia (2)
  • Stroke (2)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • Infectious Diseases (1)
  • Internal Medicine (2)
  • Pulmonary and Critical Care (1)
  • Simmons Cancer Institute (2)
Reset

Filter Results

Activity Status

  • Active, recruiting (5)

Treatment

  • (-) Breast Cancer (3)
  • (-) Diseases of the Lungs (2)
  • Abdominal Aortic Aneurysm (1)
  • Alzheimer's Disease (3)
  • Cervical Cancer (1)
  • Depression (2)
  • Endometrial Cancer (1)
  • Endometriosis (1)
  • Epilepsy (5)
  • Erectile Dysfunction (ED) (1)
  • Heart Disease (1)
  • High Blood Pressure (Hypertension) (8)
  • Leukemia (1)
  • Male Infertility (1)
  • Melanoma (1)
  • Myeloma (1)
  • Neuro-Critical Care (1)
  • Ovarian Cancer (3)
  • Parkinson's Disease (1)
  • Psoriasis (1)
  • Schizophrenia (2)
  • Stroke (2)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • Infectious Diseases (1)
  • Internal Medicine (2)
  • Pulmonary and Critical Care (1)
  • Simmons Cancer Institute (2)
Showing: 5 Results
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Trial
Infectious Diseases

A Phase 2/3, Randomized, Double-blind, Placebo-controlled, Multicenter, Prospective Study to Assess the Efficacy, Safety, and Pharmacokinetics of Orally Administered Epetraborole in Patients with Treatment-refractory Mycobacterium aviu

Active recruiting

The purpose of this clinical trial is to assess the effectiveness of Epetraborole, taken once daily, in patient populations with treatment-refractory MAC lung disease.

Eligible patients include those who currently have a positive MAC sputum culture despite receiving a combination regimen of at least 2 antimycobacterial agents administered for at least 6 months.

Contact: Katherine Martz phone217-545-4342 emailkmartz35@siumed.edu
Trial
Simmons Cancer Institute

ASND0029 "IL Believe": A Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study to Investigate the Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab, TransCon TLR7/8 Agonist, or Other Anticancer Therapies, in

Active recruiting

This study is investigating experimental drugs TransCon IL-2 β/γ and TransCon TLR7/8 for the treatment of a

Contact: Kathy Robinson phone217-545-1946 emailsciresearchbc@siumed.edu
Trial
Simmons Cancer Institute

BC-IMT-04: Randomized, Open-Label Study of the Bria-IMT Regimen and Check Point Inhibitor vs Physicians' Choice in Advanced Metastatic Breast Cancer (BRIA-ABC)

Active recruiting

This is a multicenter randomized, open label study to evaluate overall survival with the Bria-IMT regimen in combination with Checkpoint Inhibitor [Retifanlimab], versus Treatment of Patients'/Physicians' Choice (TPC) in advanced metastatic or locally recurrent breast cancer (aMBC) patients with no approved alternative therapies available.

Contact: Kathy Robinson phone217-545-1946 emailsciresearchbc@siumed.edu
Trial
Simmons Cancer Institute

EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk

Active recruiting

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-).

Contact: Kathy Robinson phone217-545-1946 emailsciresearchbc@siumed.edu
Trial
Pulmonary and Critical Care

ENCORE - A Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy and Safety of an Amikacin Liposome Inhalation Suspension (ALIS)-Based Regimen in Adult Subjects with Newly Diagnosed Nontuberculous Myco

Active recruiting

The purpose of this clinical trial is to assess the effectiveness of ARIKAYCE, inhaled once daily, in patient populations with mild and untreated MAC lung infection. 

Eligible patients include those who currently have a positive MAC sputum culture and have not received treatment for their infection.

Contact: Katherine Martz phone217-545-4342 emailkmartz35@siumed.edu
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