Clinical trials and research studies

The purpose of this study is to compare the success of a single admnistration of Staccato alprazolam compared with placebo in rapidly terminating a seizure episode within 90seconds after IMP administration.

The primary objective of this study is to assess the effect of XEN1101 versus placebo on reducing focal seizure frequency.

The primary objective is to assess the effect of XEN1101 versus placebo on reducing PGTCS frequency in subjects with PGTCS.

The primary endpoint of this study is to evaluate the long-term safety and tolerability of Staccato alprazolam.

PURPOSE: This is a biological sample collection study aimed at developing an early diagnostic tool for endometrial and ovarian cancer. The investigators are studying the relationship between estrogen driven gynecological cancers, inflammation and the microbiome. Patients who have been diagnosed with endometrial cancer or undergo presurgical evaluation for suspicion of ovarian cancer who are scheduled for a hysterectomy, bilateral oophorectomy and/or salpingectomy are eligible. Control patients undergoing gynecological surgery for benign indications are also being recruited.

To compare the effect of percutaneous coronary intervention (PCI) vs coronary artery bypass grafting (CABG)

To evaluate the efficacy of SPN-817 as a treatment for adult participants with focal onset seizures.

To evaluate the efficacy of SPN-817 as a treatment for adult participants with focal onset seizures.

The purpose of this study is to compare the success of a single admnistration of Staccato alprazolam compar

PURPOSE: The purpose of this clinical trial is to find out if the investigational study treatment, called inclisiran, can help prevent cardiovascular events (such as heart attacks, strokes, and cardiovascular-related deaths) in adults who already have been diagnosed with cardiovascular disease.