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clinical trials

Clinical trials and research studies

At SIU Medicine, our researchers perform clinical trials and research studies with the aim of translating findings into new, more effective treatments.
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Activity Status

  • (-) Active, recruiting (36)
  • Active, not recruiting (11)

Treatment

  • Alzheimer's Disease (2)
  • Breast Cancer (3)
  • Cervical Cancer (1)
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  • Erectile Dysfunction (ED) (1)
  • High Blood Pressure (Hypertension) (3)
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  • Melanoma (1)
  • Myeloma (1)
  • Ovarian Cancer (3)
  • Psoriasis (1)
  • Schizophrenia (2)
  • Stroke (2)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

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  • Simmons Cancer Institute (8)
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Filter Results

Activity Status

  • (-) Active, recruiting (36)
  • Active, not recruiting (11)

Treatment

  • Alzheimer's Disease (2)
  • Breast Cancer (3)
  • Cervical Cancer (1)
  • Depression (2)
  • Diseases of the Lungs (2)
  • Endometrial Cancer (1)
  • Endometriosis (1)
  • Epilepsy (5)
  • Erectile Dysfunction (ED) (1)
  • High Blood Pressure (Hypertension) (3)
  • Leukemia (1)
  • Male Infertility (1)
  • Melanoma (1)
  • Myeloma (1)
  • Ovarian Cancer (3)
  • Psoriasis (1)
  • Schizophrenia (2)
  • Stroke (2)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • Alzheimer's Center (2)
  • Cardiothoracic Surgery (1)
  • Dermatology (1)
  • Infectious Diseases (1)
  • Internal Medicine (6)
  • Men's health (1)
  • Neurology (7)
  • Obstetrics and Gynecology (3)
  • Pediatrics (1)
  • Psychiatry (5)
  • Pulmonary and Critical Care (3)
  • Simmons Cancer Institute (8)
  • Urology (2)
  • Vascular Surgery (1)
  • Women's health (1)
Showing: 36 Results
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Trial
Neurology

A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients with Early Alzheimer’s Disease (BenfoTeam)

Active recruiting

The purpose of this study is to learn more about the safety, effectiveness and tolerability of the study drug called Benfotiamine, to determine whether it delays or slows the progression of the symptoms of early Alzheimer’s disease.

Contact: Stephanie Kohlrus phone217-545-3013 emailskohlrus@siumed.edu
Trial
Neurology

An Open-Label, Multicenter, Outpatient Extension Study to Evaluate the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older with Stereotypical Prolonged Seizures

Active recruiting

The primary endpoint of this study is to evaluate the long-term safety and tolerability of Staccato alprazolam.

Contact: Rylee Manka phone217-545-1394 emailrmanka63@siumed.edu
Trial
Simmons Cancer Institute

ASND0029 "IL Believe": A Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study to Investigate the Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab, TransCon TLR7/8 Agonist, or Other Anticancer Therapies, in

Active recruiting

This study is investigating experimental drugs TransCon IL-2 β/γ and TransCon TLR7/8 for the treatment of a

Contact: Kathy Robinson phone217-545-1946 emailsciresearchbc@siumed.edu
Trial
Simmons Cancer Institute

BC-IMT-04: Randomized, Open-Label Study of the Bria-IMT Regimen and Check Point Inhibitor vs Physicians' Choice in Advanced Metastatic Breast Cancer (BRIA-ABC)

Active recruiting

This is a multicenter randomized, open label study to evaluate overall survival with the Bria-IMT regimen in combination with Checkpoint Inhibitor [Retifanlimab], versus Treatment of Patients'/Physicians' Choice (TPC) in advanced metastatic or locally recurrent breast cancer (aMBC) patients with no approved alternative therapies available.

Contact: Kathy Robinson phone217-545-1946 emailsciresearchbc@siumed.edu
Trial
Obstetrics and Gynecology

Biomarkers for Endometrial and Ovarian Cancer

Active recruiting

PURPOSE: This is a biological sample collection study aimed at developing an early diagnostic tool for endometrial and ovarian cancer. The investigators are studying the relationship between estrogen driven gynecological cancers, inflammation and the microbiome. Patients who have been diagnosed with endometrial cancer or undergo presurgical evaluation for suspicion of ovarian cancer who are scheduled for a hysterectomy, bilateral oophorectomy and/or salpingectomy are eligible. Control patients undergoing gynecological surgery for benign indications are also being recruited.

Contact: Kathleen Groesch phone217-545-6671 emailkgroesch@siumed.edu
Trial
Neurology

Caregiver Characteristics That May Predict When Patients With Alzheimer Disease Are Placed in Long Term Care Facilities

Active recruiting
This research will be conducted by the SIU Memory and Aging Network (MAN), which comprises 38 sites that evaluate and treat patients with dementia throughout non-metropolitan Illinois.  AD patients and their caregivers who are living in private homes will be recruited.  Primary outcome measures will be the ratings of the caregiver’s physical status (grip strength, walking speed, and score on the Timed Up-and-Go Test11 and the rating of the caregiver’s chronic medical illness burden using the Cumulative Illness Rating Scale (Geriatric).12,13  The patient and caregiver dyad is required.
Contact: Stephanie Kohlrus phone217-545-3013 emailskohlrus@siumed.edu
Trial
Psychiatry

Click: Study to Evaluate the Efficacy and Safety of a Digital Therapeutic as an Adjunct to Standard-of-Care Antipsychotic Therapy in Adult and Late Adolescent Participants with Experiential Negative Symptoms of Schizophrenia

Active recruiting

CT-155-R-001: The purpose of this study is to investigate if digital therapeutics (a moblie software application) can help treat certain symptoms of schizophrenia. 

Contact: Oladele (Dickson) Owasoyo phone217-545-7231 emailoowasoyo94@siumed.edu
Trial
Psychiatry

Click Therapeutics CT-155-R-01

Active recruiting

To evaluate the efficacy and safety of CT-155 in reducing experiential negative symptoms, compared with a Digital Control, in adult and late adolescent participants diagnosed with schizophrenia.

Contact: Oladele (Dickson) Owasoyo phone217-545-7231 emailoowasoyo94@siumed.edu
Trial
Obstetrics and Gynecology

Collection and Banking of Blood Samples for the Study of Gynecological Diseases

Active recruiting

AOA DX is developing a blood test to detect ovarian cancer (biomarker).  The purpose of this study is to collect and store donated blood samples and associated medical data from participating subjects to help develop the ovarian cancer test.

Contact: Kathy Groesch phone217-545-6671 emailkgroesch@siumed.edu
Trial
Dermatology

Corrona Psoriasis (PSO) Registry

Active recruiting

The objective of the Corrona Psoriasis Registry is to create a national database of patients with psoriasis. Data collected will be used to study the  disease and to evaluate the effectiveness and safety of medications approved for the treatment of psoriasis.

Contact: Rebecca Coughlin phone217-545-7321 emailrcoughlin59@siumed.edu
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