About the Carbondale Area Where is Carbondale, Illinois? Carbondale is a city of 25,000 near the southern tip of Illinois, in a beautiful region known as “Little Egypt” – close to the Mississippi River and on the edge of the Shawnee National Forest. It is the home of the flagship campus of Southern Illinois University. Carbondale is NOT near Chicago. It is located approximately 100 miles southeast of St. Louis, 330 miles south of Chicago, 200 miles north of Memphis, and 200 miles northwest of Nashville. Explore the town of Carbondale, IL What public transportation is available in Carbondale