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News

A General Anesthesia Versus Conscious Sedation in Transcatheter Aortic Valve Replacement; Experience From A Growing Structural Cardiology Program in the Midwest

Internal Medicine Presentations "A General Anesthesia Versus Conscious Sedation in Transcatheter Aortic Valve Replacement; Experience From A Growing Structural Cardiology Program in the Midwest" Authors: Bhandari B, Regmi M, Ibrahim A, Al-Bast B, Koester C, Parajuli P, Al-Akchar M, Buhnerkempe M, Worix A, Kulkarni A. ACP Internal Medicine Meeting. April 11-13, 2019. Philadelphia, PA. https://www.openaccessjournals.com/articles/general-anesthesia-versus-c…

News

A hyperactive brain in Alzheimer’s disease

Neurons are the cells responsible for communicating important information to different areas of the brain. They use various chemical messengers, called neurotransmitters, to pass information to one another. The most abundant neurotransmitter in the brain is glutamate, a chemical on-switch that allows neurons to generate activity in other neurons. The brain needs glutamate for many different functions, including learning and memory. Still, too much of a good thing can become harmful— as is the case with this neurotransmitter. In Alzheimer’s disease (AD), the brain accumulates too much glutamate

News

A "Little Leap" to Boost Babies' Brain Power

Between birth and age 3, a child’s brain undergoes an impressive amount of change. The brain doubles in size in its first year, and by three, it reaches 80 percent of its adult volume. This period of a child’s life is the most important for brain development—and it’s inspired a new project from SIU Medicine’s Office of Population Science and Policy. Hillsboro Area Hospital serves as a community center, routinely hosts community events, houses a gym and has a day center within the confines of the hospital walls. Partnering with physicians, academics, early childhood workers, educators and

News

A Look Back at 2018: A Message from Dr. Jerry Kruse

Dear Colleagues: On a quarterly basis, I will provide a written or video description of some of the recent activities, accomplishments, and upcoming events at SIU Medicine. I will keep you appraised of the various opportunities and challenges that are before us. These updates certainly will not include all of the important activities at SIU Medicine, but I will try to represent things that fulfill our mission and strategies, and that I will also bring to the attention of the leaders of the SIU System. This communication is a type of “News and Views” delivered right to your desktop. I will

News

A Mother's Mortality

In the U.S., giving life can be a matter of death. By Steve Sandstrom The current generation of new moms in America face a higher risk of dying during childbirth than their mothers did 25 years ago. About 700 American women die each year from pregnancy complications and about 70 percent of these deaths are preventable. Maternal morbidity (severe pregnancy complications) and mortality (death) are indicators of the overall health of a country, state or community. Among developed nations, the U.S. is one of 13 countries headed in the wrong direction, with a mortality rate comparable to Iraq and

News

A Natural Fit

Dale Buck Hales, Ph.D., finds a new home at SIU School of Medicine Written by Karen Carlson | Photographs by Jim Hawker Published in Aspects. Autumn 2008 (32-4) Dale Buck Hales, Ph.D., stood amid the towering grandeur of Giant City State Park and was in awe. The park was the first stop during his visit to Carbondale to interview for the position of chair of physiology at SIU School of Medicine. Dr. Hales was ready to hit the SIU campus, but former chairman Rick Steger, Ph,D., first took him to Giant City, a captivating introduction to the region and a profound change from Dr. Hales’ home in

News

A Open Access Scheduling for Routine and Urgent Appointments to Cardiology Clinic

Internal Medicine Presentations "A Open Access Scheduling for Routine and Urgent Appointments to Cardiology Clinic" Authors: Ibrahim A, Al-Akchar M, Bhandari B, Mahmaljy H, Al-Bast B, Ali M, Koester C, Kulkarni A. National ACP: Internal Medicine 2019, Philadelphia, PA. April 2019

Trial

Simmons Cancer Institute

A Phase 1 Study of SGN-B6A in Advanced Solid Tumors

Active recruiting

This trial looks at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors (NSCLC, HNSCC).

Trial

Simmons Cancer Institute

A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and Efficacy of BGB-11417as Monotherapy, in Combination With Dexamethasone and Carfilzomib/Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma and t(11;14)

Active recruiting

The purpose of the study is to test BGB-11417 (alone, with dexamethasone, and with carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma who test positive for t(11;14). .

Trial

Infectious Diseases

A Phase 2/3, Randomized, Double-blind, Placebo-controlled, Multicenter, Prospective Study to Assess the Efficacy, Safety, and Pharmacokinetics of Orally Administered Epetraborole in Patients with Treatment-refractory Mycobacterium aviu

Active recruiting

The purpose of this clinical trial is to assess the effectiveness of Epetraborole, taken once daily, in patient populations with treatment-refractory MAC lung disease.

Eligible patients include those who currently have a positive MAC sputum culture despite receiving a combination regimen of at least 2 antimycobacterial agents administered for at least 6 months.

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