News

Going on the offensive: The potential link between cell senescence and Alzheimer's

When you catch a cold or cut your finger, the immune system begins the healing process by clearing damaged cells. As we age, that process weakens. Health problems linger as immune systems aren’t quite as robust as they once were, whether it’s fighting bacteria, viruses, or cancer cells. Alzheimer’s researchers are now exploring a process called senescent cell accumulation to see if it could be detrimental.
Trial
Neuroscience Institute

Sleep for Stroke Management and Recovery Trial

Active recruiting

The primary goals of this study are to determine whether treatment of obstructive sleep apnea with positive airway pressure starting shortly after accute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event and (2) improves stroke outcomes at 3 months in patients who experienced ischemic stroke.

Trial
Neuroscience Institute

18-513: A Randomized Clinical Trial of Andexanet Alfa in Acute Intracranial Hemorrhage in Patients Receiving an Oral Factor XA Inhibitor

Active not recruiting

18-513:  The purpose of this study is to evaluate the effect of andexanet alfa (andexanet) versus usual care on the rate of effective homostasis.

Trial
Urology

ProVIDE: The ProVee Urethral Expander System Study: The ProVee IDE Study

Active not recruiting

The study will test whether the study device, the ProVee Urethral Expander System, can be placed in your urethra safely to treat your urinary symptoms due to your enlarged prostate.

News

Adams research efforts earn 2022 Toth Award

The Research Policy Committee honored Kristal Adams with the 2022 Frank J. Toth Award, the highest recognition for SIU School of Medicine research support personnel. Adams is a clinical research program director in the Center for Clinical Research.
News

Adams research efforts earn 2022 Toth Award

The Research Policy Committee honored Kristal Adams with the 2022 Frank J. Toth Award, the highest recognition for SIU School of Medicine research support personnel. Adams is a clinical research program director in the Center for Clinical Research.
Trial
Neurology

A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Active recruiting

The primary objective is to assess the effect of XEN1101 versus placebo on reducing PGTCS frequency in subjects with PGTCS.

Trial
Neurology

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures

Active recruiting

The primary objective of this study is to assess the effect of XEN1101 versus placebo on reducing focal seizure frequency.

Trial
Neurology

An Open-Label, Multicenter, Outpatient Extension Study to Evaluate the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older with Stereotypical Prolonged Seizures

Active recruiting

The primary endpoint of this study is to evaluate the long-term safety and tolerability of Staccato alprazolam.

Trial
Neurology

A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Outpatient, Parallel-Group Study to Assess the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older with Stereotypical Prolonged Seizures

Active recruiting

The purpose of this study is to compare the success of a single admnistration of Staccato alprazolam compared with placebo in rapidly terminating a seizure episode within 90seconds after IMP administration.

Subscribe to Research