Search | SIU School of Medicine

Showing: 52 Results

Trial

Internal Medicine

RADIANCE Continued Access Protocol (CAP): A study of the ReCor Medical Paradise System in Clinical Hypertension

Active not recruiting

The purpose of this clinical trial is to find out if a medical device called the Paradise Renal Denervation System can lower blood pressure in patients who have hypertension

Trial

Internal Medicine

Radiance US GPS: The Global Paradise® System US Post Approval Study

Active recruiting

The purpose of this clinical study is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication.

Eligible patients include those who currently have a diagnosis of high blood pressure despite having taken or are currently taking anti-hypertensive medications.

Trial

Psychiatry

RECOVER: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy System as Adjunctive Therapy Versus a No-Stimulation Control in Subjects with Treatment-Resistant Depression

Active recruiting

The RECOVER study is a nationwide clinical trial that has been approved by Medicare to provide additional evidence for the benefits of Vagus Nerve Stimulation (VNS) Therapy. Vagus Nerve Stimulation Therapy is an FDA-approved device for treating patients with TRD (Treatment Resistant Depression). It is implanted in the left chest area during a short outpatient procedure. The device delivers mild, intermittently pulsed signals to the vagus nerve in the neck that activate various parts of the brain.

Trial

Neurology

Renaissance 2: A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of SPN-817 in Adults with Focal Onset Seizures

Active recruiting

To evaluate the efficacy of SPN-817 as a treatment for adult participants with focal onset seizures.

Lab

Richardson Lab

The nervous system is complex and we still understand relatively little about the cause of or how to treat many neuropsychiatric disorders, like Autism, addiction, or schizophrenia. The two goals of our lab are to 1) develop a more complete understanding of certain neurocircuits and 2) use that information to inform we view and assess environmental and genetic contributions to neuropsychiatric disease. We use inbred and transgenic rodent models to understand how neuronal function at a cellular level may specifically determine discrete aspects of innate and learned behaviors related to sensory

Trial

Neurology

Roche: A Phase IIB, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of intravenous prasinezumab in participants with early Parkinson's disease

Active not recruiting

This study will evaluate the efficacy, safety, and pharmacokinetics of prasinezumab compared with placebo in patients with early Parkinson's disease (PD).

Lab

Sibling Play Lab

The Play Lab is led by Lisabeth DiLalla, PhD, a developmental psychologist at the SIU School of Medicine, and is home of the Southern Illinois Twins, Triplets and Siblings Study (SITSS). The lab focuses on preschoolers and the development of peer interactions and parent-child interactions from early childhood through adolescence.There are several research projects underway at the Lab. The SITSS primarily focuses on preschoolers, with various projects encompassing the development of peer interactions and parent-child interactions from preschool through adolescence.

Trial

Neuroscience Institute

Sleep for Stroke Management and Recovery Trial

Active recruiting

The primary goals of this study are to determine whether treatment of obstructive sleep apnea with positive airway pressure starting shortly after accute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event and (2) improves stroke outcomes at 3 months in patients who experienced ischemic stroke.

Trial

Urology

The Erectile Restoration Registry – IT MATTERS

Active recruiting

The purpose of this research study is to assess the impact of the BSC penile prostheses devices on quality of life in men with erectile dysfunction through the use of questionnaires. The study is an observation of your medical condition for a period of time after the initial implant of the device.

Trial

Cardiology

The "RADIANCE II" Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

Active not recruiting

The purpose of this clinical study is to see whether a medical device called the Paradise Renal Denervation System (also called The Paradise System) can lower high blood pressure in patients who are known to have hypertension

Search Results