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Alzheimer's disease (AD) is a multifactorial neurological disorder with no current cure, creating a significant medical demand. Traditional theories attribute AD to the build-up of the toxic protein amyloid beta (Aβ) and the formation of neurofibrillary tangles of tau-protein. However, emerging evidence propose that impaired mitochondrial function and metabolic activity play a crucial role in AD's development and progression. Our laboratory's primary focus is to explore and uncover effective methods for preventing and treating Alzheimer's disease. To achieve this, we apply different cutting

Alzheimer’s disease is an age-related neurodegenerative disorder that over time leads to severe memory impairment and greatly impacts patients and their loved ones. There is no cure or effective treatment for Alzheimer’s disease and recent evidence support early intervention as essential for improving disease outcome. Our lab is dedicated to finding effective preventions and treatments for Alzheimer’s disease. Research emphasis is on determining risk factors, and their associated mechanisms, that contribute to memory loss and Alzheimer’s disease that will allow for earlier diagnosis and

Our laboratory takes a geroscience approach to understanding biological processes that contribute to the pathogenesis of Alzheimer’s disease. The long-term goals of our laboratory are to: identify nonpharmacological interventions that target insulin and glutamate signaling pathways that prevent or alleviate cognitive decline and elucidate their mechanisms of action in order to identify pharmacological targets for treating Alzheimer’s disease and related dementias. To address these goals, our laboratory has several ongoing research interests examining the contribution of body temperature

The nervous system is complex and we still understand relatively little about the cause of or how to treat many neuropsychiatric disorders, like Autism, addiction, or schizophrenia. The two goals of our lab are to 1) develop a more complete understanding of certain neurocircuits and 2) use that information to inform we view and assess environmental and genetic contributions to neuropsychiatric disease. We use inbred and transgenic rodent models to understand how neuronal function at a cellular level may specifically determine discrete aspects of innate and learned behaviors related to sensory

The Play Lab is led by Lisabeth DiLalla, PhD, a developmental psychologist at the SIU School of Medicine, and is home of the Southern Illinois Twins, Triplets and Siblings Study (SITSS). The lab focuses on preschoolers and the development of peer interactions and parent-child interactions from early childhood through adolescence.There are several research projects underway at the Lab. The SITSS primarily focuses on preschoolers, with various projects encompassing the development of peer interactions and parent-child interactions from preschool through adolescence.