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clinical trials

Clinical trials and research studies

At SIU Medicine, our researchers perform clinical trials and research studies with the aim of translating findings into new, more effective treatments.
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Activity Status

  • Active, not recruiting (11)
  • Active, recruiting (40)

Treatment

  • Abdominal Aortic Aneurysm (1)
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  • Erectile Dysfunction (ED) (1)
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  • High Blood Pressure (Hypertension) (8)
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Department

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Filter Results

Activity Status

  • Active, not recruiting (11)
  • Active, recruiting (40)

Treatment

  • Abdominal Aortic Aneurysm (1)
  • Alzheimer's Disease (4)
  • Autism Spectrum Disorder (1)
  • Breast Cancer (3)
  • Cervical Cancer (1)
  • Depression (1)
  • Diseases of the Lungs (2)
  • Endometrial Cancer (1)
  • Endometriosis (1)
  • Epilepsy (9)
  • Erectile Dysfunction (ED) (1)
  • Heart Disease (2)
  • High Blood Pressure (Hypertension) (8)
  • Leukemia (1)
  • Male Infertility (1)
  • Melanoma (1)
  • Myeloma (1)
  • Neuro-Critical Care (1)
  • Ovarian Cancer (4)
  • Parkinson's Disease (1)
  • Psoriasis (1)
  • Stroke (3)
  • Transcranial Magnetic Stimulation (TMS) (1)
  • Vascular Disease (1)

Department

  • Alzheimer's Center (2)
  • Cardiology (2)
  • Cardiothoracic Surgery (1)
  • Dermatology (1)
  • Infectious Diseases (1)
  • Internal Medicine (8)
  • Men's health (1)
  • Neurology (9)
  • Obstetrics and Gynecology (3)
  • Pediatrics (1)
  • Psychiatry (1)
  • Pulmonary and Critical Care (2)
  • Simmons Cancer Institute (8)
  • Urology (3)
  • Vascular Surgery (2)
  • Women's health (1)
Showing: 51 Results
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Trial
Neurology

Caregiver Characteristics That May Predict When Patients With Alzheimer Disease Are Placed in Long Term Care Facilities

Active recruiting
This research will be conducted by the SIU Memory and Aging Network (MAN), which comprises 38 sites that evaluate and treat patients with dementia throughout non-metropolitan Illinois.  AD patients and their caregivers who are living in private homes will be recruited.  Primary outcome measures will be the ratings of the caregiver’s physical status (grip strength, walking speed, and score on the Timed Up-and-Go Test11 and the rating of the caregiver’s chronic medical illness burden using the Cumulative Illness Rating Scale (Geriatric).12,13  The patient and caregiver dyad is required.
Contact: Stephanie Kohlrus phone217-545-3013 emailskohlrus@siumed.edu
Trial
Obstetrics and Gynecology

Collection and Banking of Blood Samples for the Study of Gynecological Diseases

Active recruiting

AOA DX is developing a blood test to detect ovarian cancer (biomarker).  The purpose of this study is to collect and store donated blood samples and associated medical data from participating subjects to help develop the ovarian cancer test.

Contact: Kathy Groesch phone217-545-6671 emailkgroesch@siumed.edu
Trial
Dermatology

Corrona Psoriasis (PSO) Registry

Active recruiting

The objective of the Corrona Psoriasis Registry is to create a national database of patients with psoriasis. Data collected will be used to study the  disease and to evaluate the effectiveness and safety of medications approved for the treatment of psoriasis.

Contact: Rebecca Coughlin phone217-545-7321 emailrcoughlin59@siumed.edu
Trial
Simmons Cancer Institute

EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk

Active recruiting

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-).

Contact: Kathy Robinson phone217-545-1946 emailsciresearchbc@siumed.edu
Trial
Pulmonary and Critical Care

ENCORE - A Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy and Safety of an Amikacin Liposome Inhalation Suspension (ALIS)-Based Regimen in Adult Subjects with Newly Diagnosed Nontuberculous Myco

Active recruiting

The purpose of this clinical trial is to assess the effectiveness of ARIKAYCE, inhaled once daily, in patient populations with mild and untreated MAC lung infection. 

Eligible patients include those who currently have a positive MAC sputum culture and have not received treatment for their infection.

Contact: Katherine Martz phone217-545-4342 emailkmartz35@siumed.edu
Trial
Obstetrics and Gynecology

Endometriosis and the Microbiome

Active recruiting

PURPOSE: Endometriosis is an inflammatory disorder in which the tissue that lines the inside of the uterus (the endometrium) spreads to the pelvic and peritoneal cavities outside of the uterus. This is a biological sample collection study examining how bacteria located within the vagina, the urogenital tract and the gastrointestinal tract may affect the development of endometriosis. Investigators are also exploring how an individual’s microbiome affects their estrogen metabolism and inflammation.

Contact: Kathleen Groesch phone217-545-6671 emailkgroesch@siumed.edu
Trial
Internal Medicine

HyPhen: Hypertension Phenotype Study

Active recruiting

This is a local research study to relate heart health and various components found in your body (body fat, sodium, etc.) to high blood pressure during pregnancy, and those with apparently normal blood pressure.

Eligible participants include those with high blood pressure, those receiving treatment for their high blood pressure, women who had high blood pressure during pregnancy, and those with apparently normal blood pressure.

Contact: Kristin King phone217-545-7511 emailbpresearch@siumed.edu
Trial
Surgery

IMPROVE-AD

Active recruiting

Improving Outcomes in Vascular Disease – Aortic Dissection

Contact: Katie Blancett phone217-545-7799 emailkblancett37@siumed.edu
Trial
Psychiatry

ITI-007-601: A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Lumateperone in the Treatment of Irritability Associated with Autism Spectrum Disorder in Pediatric Patients 5 to 17 Years of Age

Active recruiting

The primary objective is to evaluate the efficacy of high and low doses of lumateperone vs placebo for the

Contact: Oladele Owasoyo phone217-545-7231 emailoowasoyo94@siumed.edu
Trial
Simmons Cancer Institute

KO-MEN-008: Phase 1 Study to Determine the Safety and Tolerability of Ziftomenib Combinations for the Treatment of KMT2A-rearranged or NPM1-mutant Relapsed/Refractory Acute Myeloid Leukemia

Active recruiting

Examining the safety, tolerability, and effectiveness of investigational drug ziftomenib in combination with standard of care treatments for patients with relapsed/refractory acute myeloid leukemia. The study drug will be examined with the following agents: FLAG-IDA, low-dose cytarabine, and gilteritinib.

Contact: Kathy Robinson phone217-545-1946 emailsciresearchbc@siumed.edu
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