Erin Hascup Lab


    Alzheimer’s disease is an age-related neurodegenerative disorder that over time leads to severe memory impairment and greatly impacts patients and their loved ones. There is no cure or effective treatment for Alzheimer’s disease and recent evidence support early intervention as essential for improving disease outcome. 

    Our lab is dedicated to finding effective preventions and treatments for Alzheimer’s disease. Research emphasis is on determining risk factors, and their associated mechanisms, that contribute to memory loss and Alzheimer’s disease that will allow for earlier diagnosis and treatment to improve patient outcome. To accomplish this, we focus on discovery of early biomarkers and intervention strategies, primarily in the areas of neurotransmission, inflammation, and cell senescence, in combination with cognitive assessments.


    Erin R. Hascup, PhD Primary Investigator

    Director, Dale and Deborah Smith Center for Alzheimer’s Research and Treatment, Associate Professor of Neurology

    Research Focus


    • Neurotransmitter Regulation in AD (NIH R01 AG057767)
    • Early Intervention in AD
    • Cell senescence in aging and AD (NIH R01 AG061937)
    • Inflammation in aging and AD (NIH R01 AG061937)
    • Disease Stage Specific AD Therapies (NIH R01 AG057767)
    • Cell senescence in epilepsy


    Hascup Lab_McFadden

    Study suggests colder environments do not improve cognition in Alzheimer’s

    New findings out of the Hascup research groups suggest the body's decline in metabolic function when aging, combined with a chronic colder environment, may increase Alzheimer’s disease progression — particularly in women.
    Ben Richardson

    $1.86M grant helps SIU scientist broaden brain research into autism

    Ben Richardson, Ph.D., has spent his career studying functions and circuits in the brain and what causes them to behave abnormally, especially within an area called the cerebellum. His work has
    Radio Alzheimers Center

    Erin Hascup discusses recent investiture, Alzheimer's research

    Dr. Erin Hascup, director of the Dale and Deborah Smith Center for Alzheimer's Research and Treatment, sat down with WMAY's Jim Leach to discuss Alzheimer's research.

    Past Lab Team Members

    • Lindsay Alewelt
    • Sarah Broderick
    • Matthew Cleveland, MD
    • MaKayla Cox
    • Nahayo Esperant-Hilaire, MD       
    • Tracey Evans, PhD
    • Patrick Fitzgerald, MD
    • Thomas Johnston
    • Nadeem Khan, MD
    • Abigail Levy, MD
    • Erik Lokaitis
    • Neha Mokhasi
    • Oladele Owasoyo, PhD
    • Sujata Pandey
    • Collin Pauly
    • Teonna Piphus
    • Shari Randall
    • Shelly Reeter
    • Hannah Roberts
    • Lindsey Sime
    • Ernesto Solis, Jr., PhD
    • Aaron Sul, MD
    • Farah Tamizuddin, MD
    • Darrow Traylor
    • Niyant Vora
    • Bradley Vost, MD