Kevin Hascup Lab

    Overview

    Our laboratory takes a geroscience approach to understanding biological processes that contribute to the pathogenesis of Alzheimer’s disease. The long-term goals of our laboratory are to:

    1. identify nonpharmacological interventions that target insulin and glutamate signaling pathways that prevent or alleviate cognitive decline and
    2. elucidate their mechanisms of action in order to identify pharmacological targets for treating Alzheimer’s disease and related dementias.

    To address these goals, our laboratory has several ongoing research interests examining the contribution of body temperature, glutamatergic neurotransmission, and glucose homeostasis on cognitive decline in mouse models of Alzheimer’s disease as well as extended longevity. These parameters are assessed by using innovative whole animal and molecular biological techniques to measure in vivo neurotransmitter dynamics, cognitive performance, and metabolism.

    Current projects

    •    Neurotransmitter dysregulation in AD (NIH R01 AG057767)
    •    Cell senescence in aging and AD (NIH R01 AG061937)
    •    COVID-19 Infection on AD (NIH R01 AG061937-S3)
    •    Core body temperature on AD pathogenesis
    •    Model organism development for AD, aging, and COVID-19
    •    Cell senescence in epilepsy

     

    News

    Research Fang Lab

    SIU earns elite Research 1 status in national rankings

    This milestone reflects the combined academic strength of the SIU campuses in Springfield and Carbondale and affirms the university’s national leadership in discovery and innovation.
    SIU School of Medicine Graduate Student at Franklin Middle School for Brain Awareness Day

    SIU Graduate Students Inspire Future Scientists at Brain Awareness Day

    When it comes to anatomy, everyone has a favorite part. Each year, graduate students from the SIU School of Medicine’s Neuroscience and Pharmacology concentration show some love to their top choice
    Dr. Hascup in laboratory

    New research internship opportunities at Smith Alzheimer's Center

    The Smith Alzheimer’s Center at SIU Medicine is offering two new lab internship opportunities for undergraduate college students in 2025. Selected students will explore cutting-edge research

    Past Lab Team Members

    • Lindsay Alewelt
    • Matthew Cleveland, MD
    • MaKayla Cox
    • Nahayo Esperant-Hilaire, MD        
    • Tracy Evans, PhD
    • Caleigh Findley, PhD
    • Patrick Fitzgerald, MD
    • Thomas Johnston
    • Nadeem Khan, MD
    • Abigail Levy, MD
    • Erik Lokaitis
    • Neha Mokhasi
    • Oladele Owasoyo, PhD
    • Sujata Pandey
    • Collin Pauly
    • Teonna Piphus
    • Hannah Roberts
    • Lindsey Sime
    • Ernesto Solis, Jr., PhD
    • Aaron Sul, MD
    • Farah Tamizuddin, MD
    • Darrow Traylor
    • Niyant Vora
    • Bradley Vost, MD