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Trial

Psychiatry

A PRospective, Multi-cEnter, Randomized Controlled Blinded Trial DemOnstrating the Safety and Effectiveness of VNS Therapy® System as AdjunctivE Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)

Active recruiting

The primary objective of this study is to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing at least a 50% reduction in baseline depressive symptom severity, based on Montgomery Åsberg Depression Rating Scale (MADRS) total score, at 12 months from randomization.

Trial

Pediatrics

A Randomized, Double Blind, Parallel-group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IBP-9414 in Premature Infants 500-1500g Birth Weight in the Prevention of Necrotizing Enterocolitis - The Connection Study

Active recruiting

The purpose of the clinical study is to compare the effectiveness of IBP-9414 treatment against placebo in preventing necrotizing enterocolitis in premature infants.

Treatments: Prevention of necrotizing enterocolitis in premature infants

Trial

Neurology

A Randomized, Double-blind, Placebo-controlled, Global Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986446, an Anti-MTBR Tau Monoclonal Antibody, in Participants with Early Alzheimer’s Disease (TargetTau-1)

Active not recruiting

The purpose of this study is to assess the effect of BMS-986446 vs placebo on delay of cognitive memory and functional decline in participants (age 50-80) with early Alzheimer's Disease.

Trial

Neurology

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures

Active recruiting

The primary objective of this study is to assess the effect of XEN1101 versus placebo on reducing focal seizure frequency.

Trial

Neurology

A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Active recruiting

The primary objective is to assess the effect of XEN1101 versus placebo on reducing PGTCS frequency in subjects with PGTCS.

Trial

Urology

A Randomized Open-Label Phase 2/3 Study of BT8009 Monotherapy or in Combination in Participants with Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)

Active recruiting

The main objective of the study is to measure how safe and effective BT8009 (zelenectide pevedotin) is when used alone and in combination with pembrolizumab in participants with locally advanced or metastatic urothelial cancer (UC).

News

A Rare Case of Refractory Torsades De Pointes with Diphenhydramine Overdose

Internal Medicine Publications A Rare Case of Refractory Torsades De Pointes with Diphenhydramine Overdose Authors: Bhadari B, Garcia OL, Ibrahim A, & Kulkarni A. (2019) Journal of the American College of Cardiology, 73(9), 2796. http://www.onlinejacc.org/content/73/9_Supplement_1/2796

News

A Rare Case of Refractory Torsades De Pointes With Diphenhydramine Overdose

Internal Medicine Presentations "A Rare Case of Refractory Torsades De Pointes With Diphenhydramine Overdose" Authors: Bhandari, B, Garcia, OL, Ibrahim, A, Kulkarni, A. Journal of the Amercian College of Cardiology. 2019;73(9):2796. Presented at the ACC Conference, March 16-18, 2019. New Orleans, LA. http://www.onlinejacc.org/content/73/9_Supplement_1/2796

News

A Rare Cause of Shortness of Breath In An Adult: Discrete Subaortic Membrane

Internal Medicine Presentations "A Rare Cause of Shortness of Breath In An Adult: Discrete Subaortic Membrane" Authors: Ibrahim A, Ali M, Al-Akchar M, Kulkarni A, Siddique M. Journal of the American College of Cardiology. March 2019;73(9):2568. http://www.onlinejacc.org/content/73/9_Supplement_1/2568

News

A Registered Dietician's Guide to a Gluten-Free Thanksgiving

This Turkey Day, give thanks for gluten-free alternatives and a little creative thinking. Just because you have celiac disease or non-celiac gluten intolerance doesn’t mean you should have to sacrifice your favorite traditional Thanksgiving meals. SIU Medicine’s Sibyl Cox, a registered dietician specializing in pediatric gastroenterology and nutrition, offers her favorite tips for keeping your tummy content this holiday season: Tip #1: Pass on the stuffed turkeys. Some turkey brines or marinades as well as injections can contain gluten, so making sure the bird is gluten-free is important

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