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Our laboratory takes a geroscience approach to understanding biological processes that contribute to the pathogenesis of Alzheimer’s disease. The long-term goals of our laboratory are to: identify nonpharmacological interventions that target insulin and glutamate signaling pathways that prevent or alleviate cognitive decline and elucidate their mechanisms of action in order to identify pharmacological targets for treating Alzheimer’s disease and related dementias. To address these goals, our laboratory has several ongoing research interests examining the contribution of body temperature